α/β hydrolase fold enzymes:: the family keeps growing
α/β hydrolase fold enzymes:: the family keeps growing
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DOI：
10.1016/s0959-440x(99)00037-8
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发表时间：
1999-12-01
影响因子：
6.8
通讯作者：
Dijkstra, BW
中科院分区：
文献类型：
--
作者：
Nardini, M;Dijkstra, BW
α/β水解酶折叠是没有明显序列相似性的蛋白质所采用的三级折叠的典型例子，但是，在进化过程中，从共同的祖先分化出来。最近解决的结构显示折叠结构和底物特异性的可变性大大增加，需要重新定义区分该家族的最小特征。
The alpha/beta hydrolase fold is a typical example of a tertiary fold adopted by proteins that have no obvious sequence similarity, but nevertheless, in the course of evolution, diverged from a common ancestor. Recently solved structures demonstrate a considerably increased variability in fold architecture and substrate specificity, necessitating the redefinition of the minimal features that distinguish the family.