Multi-therapeutic effects of human adipose-derived mesenchymal stem cells on radiation-induced intestinal injury.
Multi-therapeutic effects of human adipose-derived mesenchymal stem cells on radiation-induced intestinal injury.
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DOI：
10.1038/cddis.2013.178
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发表时间：
2013-06-20
影响因子：
9
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中科院分区：
文献类型：
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放射性肠损伤（RIII）通常发生在盆腔或腹部癌症患者中。然而，目前对这些损伤的管理是无效的。近年来，间充质干细胞（MSC）已被广泛应用于再生医学，并取得了很高的疗效。在本研究中，我们假设人脂肪间充质干细胞（hAd-MSCs）可用作治愈RIII的潜在工具。我们观察到接受全腹照射的成年Sprague-Dawley大鼠从hAd-MSC注射中受益。hAd-MSCs具有RIII愈合作用，包括抗炎、新生血管形成和维持上皮稳态，如血清IL-10升高、血管内皮生长因子、碱性成纤维细胞生长因子和表皮生长因子在辐照肠中的上调、CD 31阳性造血干细胞或造血祖细胞的动员以及Bmi 1阳性细胞在隐窝内的长期存在所示。因此，hAd-MSC治疗后，照射的大鼠比未治疗的动物存活更长时间。这些结果表明，hAd-MSCs具有治疗RIII管理的潜力。
Radiation-induced intestinal injuries (RIII) commonly occur in patients who suffer from pelvic or abdominal cancer. However, current management of these injuries is ineffective. Recently, mesenchymal stem cells (MSCs) have been extensively used in regenerative medicine and have achieved a high level of efficacy. In the present study, we hypothesised that human adipose-derived mesenchymal stem cells (hAd-MSCs) could be used as potential tools to heal RIII. We observed that adult Sprague–Dawley rats that received whole-abdominal irradiation benefitted from hAd-MSC injection. hAd-MSCs had RIII-healing effects, including anti-inflammation, neovascularisation and maintenance of epithelium homeostasis, as indicated by elevated serum IL-10, upregulation of vascular endothelial growth factor, basic fibroblast growth factor and epidermal growth factor in irradiated intestine, mobilisation of CD31-positive haematopoietic stem cells or haematopoietic progenitor cells, and the prolonged presence of Bmi1-positive cells within crypts. Consequently, after hAd-MSC treatment, irradiated rats survived longer than non-treated animals. These results suggest that hAd-MSCs have therapeutic potential for RIII management.
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