Common Marmoset Model of α-Synuclein Propagation.
Common Marmoset Model of α-Synuclein Propagation.
复制标题
α-突触核蛋白传播的常见狨猴模型。
DOI：
10.1007/978-1-0716-1495-2_13
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Hasegawa M.
中科院分区：
文献类型：
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作者：
Masuda-Suzukake M;Shimozawa A;Hashimoto M;Hasegawa M.
组装的α-突触核蛋白（αS）的增殖是理解帕金森病、路易体痴呆和多系统萎缩等突触核蛋白病的病理机制的关键，本文描述了一种利用普通绒猴（Callithrix jacchus）脑内注射合成的预制αS纤维的非人灵长类动物αS增殖模型。该方案能够观察磷酸化αS病理的形成及其在注射后3个月的传播。
The propagation of assembled α-synuclein (αS) is key to understanding the pathological mechanisms of synucleinopathies such as Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy.Here we describe a nonhuman primate model of αS propagation using common marmosets (Callithrix jacchus) with an intracerebral injection of synthetic preformed αS fibrils. This protocol enables observation of the formation of phosphorylated αS pathology and its propagation three months after the injection.