Antimicrobial Emulsifier-Glycerol Monolaurate Induces Metabolic Syndrome, Gut Microbiota Dysbiosis, and Systemic Low-Grade Inflammation in Low-Fat Diet Fed Mice
Antimicrobial Emulsifier-Glycerol Monolaurate Induces Metabolic Syndrome, Gut Microbiota Dysbiosis, and Systemic Low-Grade Inflammation in Low-Fat Diet Fed Mice
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DOI：
10.1002/mnfr.201700547
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发表时间：
2018-02-01
影响因子：
5.2
通讯作者：
Feng，Fengqin
中科院分区：
文献类型：
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作者：
Jiang，Zengliang;Zhao，Minjie;Feng，Fengqin
甘油单月桂酸酯（GML）在全球食品工业中广泛使用，被认为是安全的，但对于慢性疾病，支持的科学数据仍然很少。本研究调查饮食GML是否诱导代谢综合征、肠道微生物群失调和全身性低度炎症。方法和结果研究GML诱导的代谢综合征、肠道微生物群改变和全身性低度炎症的发生。结果表明，与对照组（CON）相比，GML通过显着增加体重、体重增加、食物摄入量、体脂、脂肪滴大小和附睾脂肪百分比、血清甘油三酯（TG）、低密度脂蛋白（LDL）和致动脉粥样硬化指数，并降低体肌比、肝脏重量和高密度脂蛋白（HDL）诱导代谢综合征。同时，GML显著改变了肠道微生物群的β多样性和组成，并上调了血清LPS、IL-1β、IL-6和TNF-α的循环水平。重要的是，GML显着降低Akkermansia muciniphilaandLupinus luteus，并增加Bacteroides acidifaciens，大肠杆菌和微生物DNA丰度的10个预测的代谢途径参与碳水化合物，氨基酸，和lipid metabolism.ConclusionOur结果表明，相对低剂量的GML消费促进代谢综合征，肠道微生物群生态失调，和全身性低度炎症，从而呼吁重新评估GML的使用。
ScopeGlycerol monolaurate (GML) is widely consumed worldwide in the food industry and is considered safe, but for chronic diseases, supporting scientific data remain sparse. This study investigates whether dietary GML induces metabolic syndrome, gut microbiota dysbiosis, and systemic low‐grade inflammation.Methods and resultsGML‐induced occurrence of metabolic syndrome, gut microbiota alterations, and systemic low‐grade inflammation are investigated. The results demonstrate that GML induced metabolic syndrome by significantly increasing the body weight, weight gain, food intake, body fat, fat droplet size and percentage of epididymal fat, serum triglycerides (TG), LDL, and atherogenic index, and decreasing the body muscle ratio, liver weight, and HDL, compared to the control (CON) group. Meanwhile, GML significantly changed the β‐diversity and composition of gut microbiota and upregulated the circulating levels of serum LPS, IL‐1β, IL‐6, and TNF‐α. Importantly, GML significantly decreasedAkkermansia muciniphilaandLupinus luteus, and increasedBacteroides acidifaciens,Escherichia coliand the microbial DNA abundance of the ten predicated metabolism pathways involved in carbohydrate, amino acid, and lipid metabolism.ConclusionOur results indicate that relatively low‐dose GML consumption promotes metabolic syndrome, gut microbiota dysbiosis, and systemic low‐grade inflammation, thereby calling for a reassessment of GML usage.