Heart Cycle Length Modulation by Electrical Neurostimulation in the High Right Human Atrium
Heart Cycle Length Modulation by Electrical Neurostimulation in the High Right Human Atrium
复制标题
通过电神经刺激调节人类高位右心房的心动周期长度
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
S. Leonhardt
中科院分区：
文献类型：
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作者：
Antje Pohl;B. Bellmann;N. Hatam;P. Schauerte;S. Leonhardt
今天，无论潜在的冠状动脉疾病如何，高静息心率已被认为是总体死亡率较高的独立危险因素。神经刺激是一种通过电刺激特定神经细胞来治疗各种疾病的快速、广泛的方法。我们提出了一种心内神经刺激副交感神经张力的技术，在窦房结区域的人的高右心房。研究包括记录心率下降的影响，右心房的心内膜解剖可视化，以及开发副交感神经束和交感神经束的梯度图。在窦性节律内的消融过程中，患者被双极电极导管刺激，该导管可以被电解剖导航系统检测到。记录刺激前、中、后的窦性心动周期长度和相应的室性心率，并与刺激的开始和结束直接相关。
Today, high resting heart rates are known to be an independent risk factor for a higher overall mortality, irrespective of underlying coronary diseases. Neurostimulation is a fast growing, wide spread approach to treat various disorders by electrical stimulation of specific nerve cells. We present a technique of intracardiac neurostimulation to the parasympathetic tone in the high right human atrium in the sinoatrial node area. Investigations include recording the decreasing effects of heart rate, the anatomical endocardial visualization of the right atrium, and developing gradient maps with parasympathetic and sympathetic nerve bundles. During an ablation procedure within the sinus rhythm, patients are stimulated with a bipolar electrode catheter which can be detected by an electroanatomical navigation system. Sinus cycle length and corresponding ventricular heart rate are recorded before, during and after stimulation and show a direct correlation with the start and end of stimulation.