Flow of edema fluid into pulmonary airways.
Flow of edema fluid into pulmonary airways.
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水肿液流入肺气道。
DOI：
10.1152/jappl.1983.55.4.1262
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
R. Effros
中科院分区：
文献类型：
--
作者：
G. Mason;R. Effros
使用原位兔制剂来表征左心房压力升高时水肿液进入气道的方式。气道最初充满液体，以尽量减少水肿液逆流进入肺泡。气道溶液含有 125I-白蛋白，在一些研究中含有[14C]蔗糖，并且用类似的溶液灌注肺部，其中含有用伊文思蓝染料和 99mTc-二亚乙基三胺五乙酸盐 (DTPA) 或 99mTc-硫胶体颗粒（0.4-1.7 微米直径）标记的白蛋白。灌注30分钟后，将液体从气道泵入连续管中。当左心房压力较低时，气道和灌注液之间可检测到的标记转移非常少。然而，当左心房压力增加至 15 或 22 cmH2O 时，进入气道的液体含有与灌注液中浓度大致相同的伊文思蓝染料和 99mTc-DTPA。相比之下，胶体颗粒的浓度平均低于灌注液浓度的 5%，表明液体没有通过分隔血管和气道隔室的屏障的撕裂逸出。从气道泵出的初始样本中，灌注液和指示剂的浓度最高。这些观察结果表明，进入气道的一些液体可能来自支气管周围套囊，或者肺泡水肿形成存在明显的区域差异。
An in situ rabbit preparation was used to characterize the manner in which edema fluid enters the airways when left atrial pressures are elevated. The airways were initially filled with fluid to minimize retrograde flow of edema fluid into the alveoli. The airway solution contained 125I-albumin and in some studies [14C]sucrose, and the lungs were perfused with a comparable solution which contained albumin labeled with Evans blue dye and 99mTc-diethylenetriaminepentaacetate (DTPA) or 99mTc-sulfur-colloid particles (0.4-1.7 micron diam). After 30 min of perfusion, fluid was pumped from the airways into serial tubes. When left atrial pressures were low, there was very little transfer of labels detectable between the airway and perfusate solutions. However when left atrial pressures were increased to either 15 or 22 cmH2O, fluid entered the airways containing approximately the same concentrations of Evans blue dye and 99mTc-DTPA as those present in the perfusate. In contrast, the concentration of colloid particles averaged less than 5% perfusate concentrations, indicating that the fluid had not escaped through a tear in the barriers separating the vascular and airway compartments. Concentrations of the perfusate fluid and indicators were highest in the initial samples pumped from the airways. These observations suggest that some of the fluid entering the airways may be derived from peribronchial cuffs or that there are marked regional differences in edema formation from alveoli.