Neuropathological basis of nonmotor manifestations of Parkinson's disease.
Neuropathological basis of nonmotor manifestations of Parkinson's disease.
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DOI：
10.1002/mds.26605
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Beach TG
中科院分区：
文献类型：
--
作者：
Adler CH;Beach TG
帕金森病（PD）的非运动表现可以在运动PD开始之前开始。现在很清楚，从临床和尸检研究中，有显着的路易型α-突触核蛋白病目前以外的黑质-纹状体途径，这可能是这些非运动表现的基础。这篇综述将讨论神经病理学的发现，可能是潜在的非运动症状，无论是早于运动的发现或发生的疾病进展。
Non-motor manifestations of Parkinson’s disease (PD) can begin well before motor PD begins. It is now clear, from clinical and autopsy studies, that there is significant Lewy type alpha-synucleinopathy present outside the nigro-striatal pathway, and that this may underlie these non-motor manifestations. This review will discuss neuropathological findings that may underlie non-motor symptoms that either predate motor findings or occur as the disease progresses.