Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: Modification by lymphotoxin alpha
Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: Modification by lymphotoxin alpha
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DOI：
10.1093/aje/kwj294
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发表时间：
2006-11-15
影响因子：
5
通讯作者：
Witte, John S.
中科院分区：
文献类型：
--
作者：
Liu, Xin;Plummer, Sarah J.;Witte, John S.
非甾体类抗炎药（NSAIDs）对前列腺癌的潜在保护作用可能仅存在于某些男性亚群中，例如那些具有特定炎症反应基因变异的男性。为了研究这一点，作者进行了一项病例对照研究（n = 1012），研究了2001年至2004年在俄亥俄州招募的非甾体抗炎药与晚期前列腺癌之间的关系，并评估了这种关系是否被淋巴素α (LTA)基因（LTA C+80A，其中CC基因型导致更高的LTA产生）的功能多态性所改变。作者观察到阿司匹林或布洛芬的使用与疾病呈负相关（优势比= 0.67,95%可信区间：0.52,0.87）。LTA C+80A变异修正了这一点（相互作用的p = 0.03）：在CC基因型男性中，非甾体抗炎药与前列腺癌之间的负相关明显更强（优势比= 0.43,95%可信区间：0.28,0.67）。对于没有CC基因型的男性，非甾体抗炎药的使用与疾病无关（p = 0.30）。在检查非甾体抗炎药使用的剂量/持续时间时，作者观察到类似的关联。这表明，任何潜在的非甾体抗炎药对前列腺癌的化学预防可能最适合LTA +80CC基因型的男性。
The potentially protective effect of nonsteroidal antiinflammatory drugs (NSAIDs) on prostate cancer may only exist among certain subgroups of men, such as those with particular variants in inflammatory response genes. To investigate this, the authors undertook a case-control study (n = 1,012) of the association between NSAIDs and more advanced prostate cancer in Ohio men recruited between 2001 and 2004 and evaluated whether this association was modified by a functional polymorphism in the lymphotoxin alpha (LTA) gene (LTA C+80A, where the CC genotype results in higher LTA production). The authors observed an inverse association between aspirin or ibuprofen use and disease (odds ratio = 0.67, 95% confidence interval: 0.52, 0.87). This was modified by the LTA C+80A variant (p for interaction = 0.03): Among men with the CC genotype, the inverse association between NSAIDs and prostate cancer was substantially stronger (odds ratio = 0.43, 95% confidence interval: 0.28, 0.67). For men without the CC genotype, NSAID use was not associated with disease (p = 0.30). The authors observed similar associations when examining dose/duration of NSAID use. This suggests that any potential chemoprevention of prostate cancer by NSAIDs may be most appropriate for men with the LTA +80CC genotype.