Initiation of DNA synthesis of stationary human glia-like cells by a polypeptide fraction from human plasma containing somatomedin activity.
Initiation of DNA synthesis of stationary human glia-like cells by a polypeptide fraction from human plasma containing somatomedin activity.
复制标题
通过来自人血浆的含有生长调节素活性的多肽组分启动静止的人神经胶质样细胞的 DNA 合成。
DOI：
10.1016/s0014-4827(75)80036-x
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发表时间：
1975
影响因子：
3.7
通讯作者：
K. Uthne
中科院分区：
文献类型：
--
作者：
B. Westermark;Å. Wasteson;K. Uthne
从人血浆中分离出的分子量为4000-7000的多肽组分，可解除血清剥夺或密度抑制的人神经胶质细胞的细胞周期阻滞。造成这种效应的因素不是胰岛素。相同的多肽组分先前显示出增强鸡胚软骨的硫酸化和DNA合成。通过等电聚焦的分离暗示负责神经胶质细胞刺激的因子与软骨中的活性因子不相同。
A polypeptide fraction, mol.wt 4000–7000, isolated from human plasma, released the cell cycle block of serum-deprived or density-inhibited human glial cells. The factor responsible for this effect was not insulin. The same polypeptide fraction was previously shown to enhance sulphation and DNA synthesis of embryonic chick cartilage. Separation by isoelectric focusing implied that the factor responsible for the glial cell stimulation was not identical to that active in cartilage.