Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats.
Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats.
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DOI：
10.1016/j.bbrc.2010.01.095
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发表时间：
2010-02-26
影响因子：
3.1
通讯作者：
Fujiwara, Yukio
中科院分区：
文献类型：
--
作者：
Nagai, Ryoji;Nagai, Mime;Shimasaki, Satoko;Baynes, John W.;Fujiwara, Yukio
关键词：
虽然许多水果如柠檬和橙子都含有柠檬酸，但人们对柠檬酸对健康的有益作用知之甚少。我们观察了柠檬酸对链脲佐菌素诱导的糖尿病大鼠糖尿病并发症发病机制的影响。虽然口服柠檬酸对糖尿病大鼠的血糖浓度没有影响，但它延缓了白内障的发展，抑制了晚期糖基化终产物（AGEs）如Nε-（羧乙基）赖氨酸（CEL）和Nε-（羧甲基）赖氨酸（CML）在晶状体蛋白中的积累，并防止白蛋白尿和酮症。我们还发现，蛋白质与丙酮（丙酮单加氧酶由丙酮形成的代谢物）孵育产生CEL，这表明柠檬酸抑制酮症可能导致晶状体蛋白中CEL的减少。这些结果表明，在1型糖尿病动物模型中，口服柠檬酸可以改善酮症并防止糖尿病并发症的发生。
Although many fruits such as lemon and orange contain citric acid, little is known about beneficial effects of citric acid on health. Here we measured the effect of citric acid on the pathogenesis of diabetic complications in streptozotocin-induced diabetic rats. Although oral administration of citric acid to diabetic rats did not affect blood glucose concentration, it delayed the development of cataracts, inhibited accumulation of advanced glycation end products (AGEs) such as Nε-(carboxyethyl)lysine (CEL) and Nε-(carboxymethyl)lysine (CML) in lens proteins, and protected against albuminuria and ketosis . We also show that incubation of protein with acetol, a metabolite formed from acetone by acetone monooxygenase, generate CEL, suggesting that inhibition of ketosis by citric acid may lead to the decrease in CEL in lens proteins. These results demonstrate that the oral administration of citric acid ameliorates ketosis and protects against the development of diabetic complications in an animal model of type 1 diabetes.
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影响因子：
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