Morphological features in anterior scleral inflammation using swept-source optical coherence tomography with multiple B-scan averaging
Morphological features in anterior scleral inflammation using swept-source optical coherence tomography with multiple B-scan averaging
复制标题
DOI：
10.1136/bjophthalmol-2016-308561
复制
发表时间：
2017-04-01
影响因子：
4.1
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Kuroda, Yoshimasa;Uji, Akihito;Yoshimura, Nagahisa
背景/目的 使用扫源光学相干断层扫描确定前巩膜炎症的形态学特征。方法在这项回顾性观察研究中，我们检查了 14 名弥漫性前巩膜炎症患者的 17 只眼睛和 13 名年轻未受影响患者的 13 只眼睛。我们比较了使用配备多次 B 扫描平均处理的扫源光学相干断层扫描在正常眼睛和患有表层巩膜炎和巩膜炎的眼睛之间获得的结膜、巩膜外层和巩膜的横截面图像。结果光学相干断层扫描显示患病眼睛的结膜基质/外层巩膜层明显肿胀。患有弥漫性前巩膜炎症的眼睛比正常眼睛具有显着更厚的结膜基质/巩膜外层（403.0μm vs 288.0μm，p=0.002）。前巩膜炎症眼与正常眼之间巩膜基质厚度无显着差异（464.7μm vs 434.2μm，p=0.11）。我们分别分析了 11 只患有弥漫性巩膜炎的眼睛和 6 只患有弥漫性巩膜外层炎的眼睛。虽然弥漫性巩膜炎眼的结膜上皮和结膜基质/巩膜外层比弥漫性巩膜外层炎眼更厚（分别为 78.9 μm vs 50.4 μm，p = 0.003 和 445.5 μm vs 308.8 μm，p = 0.033），但弥漫性巩膜炎眼的巩膜基质厚度与正常眼相当。 (465.5μm vs 434.2μm，p=0.43)。结论弥漫性巩膜炎的肿胀发生在巩膜外层而不是巩膜基质内。由于光学相干断层扫描可以显示巩膜外层和巩膜的形态，因此它可用于评估弥漫性巩膜炎的炎症活动和治疗效果。
Background/aims To determine the morphological features of anterior scleral inflammation using sweptsource optical coherence tomography.Methods In this retrospective observational study, we examined 17 eyes of 14 patients with diffuse anterior scleral inflammation and 13 eyes of 13 young unaffected patients. We compared cross-sectional images of the conjunctiva, episclera and sclera obtained using sweptsource optical coherence tomography equipped with a multiple B-scan averaging process between normal eyes and those with episcleritis and scleritis.Results Optical coherence tomography showed that the conjunctival stroma/episclera layer was notably swollen in diseased eyes. The eyes with diffuse anterior scleral inflammation had a significantly thicker conjunctival stroma/episclera than normal eyes (403.0 mu m vs 288.0 mu m, p= 0.002). There was no significant difference in scleral stroma thickness between eyes with anterior scleral inflammation and normal eyes (464.7 mu m vs 434.2 mu m, p= 0.11). We separately analysed 11 eyes with diffuse scleritis and 6 eyes with diffuse episcleritis. While the conjunctival epithelium and conjunctival stroma/episclera were thicker in eyes with diffuse scleritis than in those with diffuse episcleritis (78.9 mu m vs 50.4 mu m, p= 0.003 and 445.5 mu m vs 308.8 mu m, p= 0.033, respectively), the scleral stroma thickness in eyes with diffuse scleritis was comparable with normal eyes (465.5 mu m vs 434.2 mu m, p= 0.43).Conclusions The swelling of diffuse scleritis occurred within the episclera rather than in the scleral stroma. Since optical coherence tomography visualises the morphology of the episclera and sclera, it can be useful for evaluating inflammation activity and therapeutic effects in diffuse scleritis.