Classification of sensitivity or resistance of cervical cancers to ionizing radiation according to expression profiles of 62 genes selected by cDNA microarray analysis
Classification of sensitivity or resistance of cervical cancers to ionizing radiation according to expression profiles of 62 genes selected by cDNA microarray analysis
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DOI：
10.1038/sj.neo.7900251
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发表时间：
2002-07-01
期刊：
影响因子：
4.8
通讯作者：
Nakamura, Y
中科院分区：
文献类型：
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作者：
Kitahara, O;Katagiri, T;Nakamura, Y
为了确定一组与宫颈鳞癌放射敏感性相关的基因，并建立一种预测方法，我们在一个由23040个人类基因组成的基因芯片上，比较了治疗前经活检获得的9例放射敏感性肿瘤和10例放射抵抗肿瘤的表达谱。我们发现121个基因在辐射敏感细胞中的表达显著高于辐射抵抗细胞，50个基因在辐射抵抗细胞中的表达水平高于辐射敏感细胞。其中一些基因已被认为与辐射反应有关，如乙醛脱氢酶1(ALDH1)和X射线修复交叉互补基因5(XRCC5)(P
To identify a set of genes related to radiosensitivity of cervical squamous cell carcinomas and to establish a predictive method, we compared expression profiles of 9 radiosensitive and 10 radioresistant tumors obtained by biopsy before treatment, on a cDNA microarray consisting of 23,040 human genes. We identified 121 genes whose expression was significantly greater in radiosensitive cells than in radioresistant cells, and 50 genes that showed higher levels of expression in radioresistant cells than in radiosensitive cells. Some of these genes had already known to be associated with the radiation response, such as aldehyde dehydrogenase 1 (ALDH1) and X-ray repair cross-complementing 5 (XRCC5) (P