Association of hypoadiponectinemia with coronary artery disease in men
Association of hypoadiponectinemia with coronary artery disease in men
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DOI：
10.1161/01.atv.0000048856.22331.50
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发表时间：
2003-01-01
影响因子：
8.7
通讯作者：
Matsuzawa, Y
中科院分区：
文献类型：
--
作者：
Kumada, M;Kihara, S;Matsuzawa, Y
背景-脂联素是一种脂肪细胞衍生的血浆蛋白，在受损动脉中积聚，具有潜在的抗动脉粥样硬化特性。本研究旨在确定血浆脂联素水平降低（低脂联素血症）是否与冠状动脉疾病（CAD）的患病率独立相关。方法和结果-连续纳入225名接受冠状动脉造影的住院患者。年龄匹配的自愿献血者 (n=225) 作为对照。 CAD 患者的血浆脂联素水平显着低于对照组。包括血浆脂联素水平、糖尿病、血脂异常、高血压、吸烟习惯和体重指数在内的多元逻辑回归分析显示，低脂联素血症与 CAD 显着且独立相关（P
Background-Adiponectin is an adipocyte-derived plasma protein that accumulates in the injured artery and has potential antiatherogenic properties. This study was designed to determine whether a decreased plasma adiponectin level (hypoadiponectinemia) can be independently associated with the prevalence of coronary artery disease (CAD).Methods and Results-The consecutive 225 male patients were enrolled from inpatients who underwent coronary angiography. Voluntary blood donors (n=225) matched for age served as controls. Plasma adiponectin levels in the CAD patients were significantly lower than those in the control subjects. Multiple logistic regression analysis including plasma adiponectin level, diabetes mellitus, dyslipidemia, hypertension, smoking habits, and body mass index revealed that hypoadiponectinemia was significantly and independently correlated with CAD (P