Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits.
Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits.
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DOI：
10.1007/s00394-011-0192-5
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发表时间：
2011-08
影响因子：
5
通讯作者：
Schechter AN
中科院分区：
文献类型：
--
作者：
Machha A;Schechter AN
在过去的十年中，越来越多的科学和医学兴趣已经出现对膳食亚硝酸盐和硝酸盐的心血管效应;然而，许多关于其作用模式的问题仍然没有答案。在这篇综述中，我们重点关注多种机制，可能占潜在的心血管有益的影响，膳食亚硝酸盐和硝酸盐。膳食亚硝酸盐和硝酸盐对心血管健康的有益变化可能来自几种机制，包括它们还原成一氧化氮，改善内皮功能，血管舒张和/或抑制血小板聚集。从最近获得的证据来看，长期以来对口服亚硝酸盐或硝酸盐毒性的担忧似乎被夸大了。膳食亚硝酸盐和硝酸盐可能对健康个体和心血管疾病患者都具有心血管保护作用。亚硝酸盐和硝酸盐在一氧化氮生物合成和/或改善一氧化氮生物利用度中的作用可能最终为使用膳食亚硝酸盐和硝酸盐补充剂治疗和预防心血管疾病提供了理论基础。
In the last decade, a growing scientific and medical interest has emerged toward cardiovascular effects of dietary nitrite and nitrate; however, many questions concerning their mode of action(s) remain unanswered. In this review, we focus on multiple mechanisms that might account for potential cardiovascular beneficial effects of dietary nitrite and nitrate. Beneficial changes to cardiovascular health from dietary nitrite and nitrate might result from several mechanism(s) including their reduction into nitric oxide, improvement in endothelial function, vascular relaxation, and/or inhibition of the platelet aggregation. From recently obtained evidence, it appears that the longstanding concerns about the toxicity of oral nitrite or nitrate are overstated. Dietary nitrite and nitrate may have cardiovascular protective effects in both healthy individuals and also those with cardiovascular disease conditions. A role for nitrite and nitrate in nitric oxide biosynthesis and/or in improving nitric oxide bioavailability may eventually provide a rationale for using dietary nitrite and nitrate supplementation in the treatment and prevention of cardiovascular diseases.
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DOI：
10.1073/pnas.74.8.3203
发表时间：
1977-01-01
影响因子：
11.1
作者：
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影响因子：
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作者：
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