CARDIOVASCULAR EFFECTS OF SODIUM-NITROPRUSSIDE IN CEREBRAL ANEURYSM SURGERY
CARDIOVASCULAR EFFECTS OF SODIUM-NITROPRUSSIDE IN CEREBRAL ANEURYSM SURGERY
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DOI：
10.1111/j.1399-6576.1980.tb01577.x
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发表时间：
1980-01-01
影响因子：
2.1
通讯作者：
RUDEHILL, A
中科院分区：
文献类型：
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作者：
LAGERKRANSER, M;GORDON, E;RUDEHILL, A
在 17 名接受脑动脉瘤手术且控制性低血压的患者中研究了硝普钠 (SNP) 的心血管作用。还计算了 10 名患者的 O2 摄取量。由于总外周阻力 (29%) 和心输出量 (15%) 的降低，SNP 使平均动脉血压从 91 毫米汞柱降低至 58 毫米汞柱。低血压期间，平均右心房和肺毛细血管楔压降低。整个过程中总 O2 吸收量保持恒定。低血压期间动脉O2张力无显着变化，但停止SNP输注后显着升高。讨论了 SNP 对近期蛛网膜下腔出血患者血流动力学的影响及其对血氧的影响。心输出量的下降与中心血容量的减少有关，并且这些患者的情况可能比正常人更为明显。
Cardiovascular effects of sodium nitroprusside (SNP) were studied in 17 patients undergoing cerebral aneurysm surgery under controlled hypotension. In 10 patients O2 uptake was also calculated. Mean arterial blood pressure was decreased from 91 to 58 mmHg by SNP due to reductions in both total peripheral resistance (29%) and cardiac output (15%). Mean right atrial and pulmonary capillary wedge pressures were reduced during hypotension. Total O2 uptake remained constant throughout the procedure. There was no significant change in arterial O2 tension in the hypotensive period, but after discontinuation of SNP infusion it was significantly increased. The hemodynamic effects of SNP in patients with a recent subarachnoid hemorrhage and its effect on blood oxygenation are discussed. The fall in cardiac output is related to a reduction of central blood volume and might be more pronounced in these patients than in normal subjects.