Antidepressant drug treatment modifies the neural processing of nonconscious threat cues
Antidepressant drug treatment modifies the neural processing of nonconscious threat cues
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DOI：
10.1016/j.biopsych.2005.10.015
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发表时间：
2006-05-01
影响因子：
10.6
通讯作者：
Goodwin, GM
中科院分区：
文献类型：
--
作者：
Harmer, CJ;Mackay, CE;Goodwin, GM
背景资料：杏仁核被认为在处理情绪突出、威胁相关的事件中起着关键作用，这些事件需要皮层区域进一步在线处理。抑郁和焦虑等情绪障碍与杏仁核的过度活跃有关，但目前尚不清楚抗抑郁治疗是否直接影响杏仁核对情绪重要信息的反应。目前的研究评估了7天给药选择性5-羟色胺再摄取抑制剂（SSRI）西酞普兰的效果，使用血氧水平依赖（BOLD）功能磁共振成像研究了从未抑郁过的志愿者对恐惧和快乐面部表情的掩蔽表现的杏仁核反应。一个双盲，组间设计与志愿者随机分配到20毫克/天西酞普兰与placebo.Results：志愿者接受西酞普兰表现出减少杏仁核反应掩蔽介绍的威胁相比，那些接受安慰剂。西酞普兰也减少了海马和内侧前额叶皮层（mPFC）的反应，特别是在恐惧相关的刺激。这些神经差异伴随着对扫描后评估的恐惧面部表情的识别减少。相比之下，有没有影响西酞普兰的神经或行为反应的快乐的面部表情。结论：这些结果表明，在人类杏仁核的威胁相关的刺激，5-羟色胺增强的直接影响。这种影响可能是重要的抗抑郁药在抑郁症和焦虑症的治疗作用。
Background: The amygdala is believed to play a key role in processing emotionally salient, threat-relevant, events that require further online processing by cortical regions. Emotional disorders such as depression and anxiety have been associated with hyperactivity of the amygdala, but it is unknown whether antidepressant treatment directly affects amygdala responses to emotionally significant information.Methods: The current study assessed the effects of 7 days administration of the selective serotonin reuptake inhibitor (SSRI) citalopram, on amygdala responses to masked presentations of fearful and happy facial expressions in never-depressed volunteers using blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging. A double-blind, between-groups design was used with volunteers randomized to 20 mg/day citalopram versus placebo.Results: Volunteers receiving citalopram showed decreased amygdala responses to masked presentations of threat compared with those receiving placebo. Citalopram also reduced responses within the hippocampus and medial prefrontal cortex (mPFC) specifically during the fear relevant stimuli. These neural differences were accompanied by decreased recognition of fearful facial expressions assessed after the scan. By contrast, there was no effect of citalopram on the neural or behavioral response to the happy facial expressions.Conclusions: These results suggest a direct effect of serotonin potentiation on amygdala response to threat-relevant stimuli in humans. Such effects may be important in the therapeutic actions of antidepressants in depression and anxiety.