Niraparib as a therapeutic agent for the treatment of ovarian cancer meningeal dissemination with BRCA1 mutation
Niraparib as a therapeutic agent for the treatment of ovarian cancer meningeal dissemination with BRCA1 mutation
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尼拉帕尼作为治疗 BRCA1 突变卵巢癌脑膜播散的治疗剂
DOI：
10.1111/jog.15663
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发表时间：
2023
影响因子：
1.6
通讯作者：
Kajiyama Hiroaki
中科院分区：
文献类型：
--
作者：
Nei Takashi;Tamauchi Satoshi;Ikeda Yoshiki;Yoshikawa Nobuhisa;Niimi Kaoru;Kajiyama Hiroaki
本研究分析了一名患有遗传性 BRCA1 突变的 63 岁女性。她在接受高级别浆液性卵巢癌（HGSOC）新辅助化疗后接受了间隔减瘤手术。术后化疗2年后，她出现头痛、头晕，并在左侧卵巢发现疑似转移性小脑肿块。肿块的病理分析显示有 HGSOC，并通过手术切除。术后8个月和另外6个月，出现局部复发；因此，她接受了射波刀治疗。 3个月后，发现颈脊髓转移，表现为左肩疼痛。此外，马尾周围存在脑膜播散。包括贝伐珠单抗在内的化疗无效，并且观察到病变增加。在射波刀治疗颈髓转移瘤后，开始尼拉帕尼治疗脑膜播散。在尼拉帕尼治疗 8 个月内，小脑病变和脑膜播散得到改善。尽管脑膜播散的治疗具有挑战性，但尼拉帕尼可能对 BRCA 突变的 HGSOC 有用。
This study analyzed a 63‐year‐old woman with hereditaryBRCA1mutation. She underwent interval debulking surgery after neoadjuvant chemotherapy for high‐grade serous ovarian carcinoma (HGSOC). After 2 years of postoperative chemotherapy, she developed headache and dizziness, and a suspected metastatic cerebellar mass in left ovary was detected. Pathological analysis of the mass revealed HGSOC, which was removed surgically. Eight months and another 6 months after the surgery, local recurrence was noted; hence, she underwent CyberKnife treatment. After 3 months, cervical spinal cord metastasis was found, evidenced by left shoulder pain. Moreover, meningeal dissemination was present around the cauda equina. Chemotherapy treatment, including bevacizumab, was ineffective and increased lesions were observed. After CyberKnife treatment for the cervical spinal cord metastasis, niraparib was initiated for the meningeal dissemination. The cerebellar lesions and meningeal dissemination improved within 8 months of niraparib treatment. Although meningeal dissemination is challenging to treat, niraparib may be useful inBRCA‐mutated HGSOC.
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