Enterocyte progenitors can dedifferentiate to replace lost Lgr5+ intestinal stem cells revealing that many different progenitor populations can regain stemness.
Enterocyte progenitors can dedifferentiate to replace lost Lgr5+ intestinal stem cells revealing that many different progenitor populations can regain stemness.
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DOI：
10.21037/sci.2016.09.15
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发表时间：
2016-10
影响因子：
--
通讯作者：
Jennifer C. Jones;P. Dempsey
中科院分区：
文献类型：
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作者：
Jennifer C. Jones;P. Dempsey
衬在胃肠道的上皮具有许多功能，包括帮助消化、营养吸收、屏障功能和免疫。在小肠中，肠上皮由重复的隐窝-绒毛单位组成，这些单位不断更新以维持肠道内稳态和组织完整性（1）。多能性肠干细胞（ISCs）位于隐窝的基础负责不断更新和快速补充细胞衬隐窝绒毛轴。ISC产生快速增殖的传递放大（TA）细胞群，当它们离开隐窝时，分化成四种主要的成熟细胞类型：肠内分泌细胞、杯状细胞和潘氏细胞属于分泌谱系，而肠细胞包括吸收谱系。虽然人们一致认为每个隐窝都含有ISCs，但干细胞群体的确切身份已争论多年（2，3）。
The epithelium lining the gastrointestinal tract serves many functions, including aiding in digestion, nutrient absorption, barrier function, and immunity. In the small intestine, the intestinal epithelium is comprised of repeating crypt-villus units which undergo constant renewal to maintain intestinal homeostasis and tissue integrity (1). Multipotent intestinal stem cells (ISCs) located in the base of the crypt are responsible for constant renewal and rapid replenishment of cells lining the crypt-villus axis. ISCs give rise to rapidly proliferating transit-amplifying (TA) cell population which, as they exit crypt, differentiate into the four major mature cell types: enteroendocrine cells, goblet cells, and Paneth cells belong to the secretory lineage, while enterocytes comprise the absorptive lineage. Although it is agreed upon that each crypt contains ISCs, the exact identity of the stem cell population has been debated for many years (2,3).