Role of Genetic Factors in Lower- and Higher-Order Aberrations - The Genes in Myopia Twin Study
Role of Genetic Factors in Lower- and Higher-Order Aberrations - The Genes in Myopia Twin Study
复制标题
DOI：
10.1159/000209667
复制
发表时间：
2009-01-01
影响因子：
2.1
通讯作者：
Baird, P. N.
中科院分区：
文献类型：
--
作者：
Dirani, M.;Chamberlain, M.;Baird, P. N.
目的：我们打算使用近视基因双胞胎研究中招募的双胞胎亚组来研究波前像差的相对遗传贡献，并随后为未来研究单色像差的病因学提供方向。据我们所知，近视双胞胎基因研究是第一个探索遗传因素在高加索人群中低阶和高阶畸变中的作用的研究。方法：每个人都完成了一份一般问卷，并进行了全面的眼科检查。高阶波前像差的计算与泽尼克系数高达四阶。结果：共有46对双胞胎，平均年龄为65.3岁。单卵双生子离焦像差的配对内相关性显著高于双卵双生子（p < 0.05）。确定了高阶畸变的遗传成分趋势。结论：屈光的遗传学研究通常探索低阶像差（如近视和远视）的遗传效应;然而，很少或没有研究高阶像差的遗传基础。近视双胞胎基因研究表明了高阶像差的潜在遗传作用，并为屈光不正的病因学提供了有用的见解。版权所有（C）2009 S. Karger AG，巴塞尔
Aims: We intended to investigate the relative genetic contribution in wavefront aberrations using a sub-group of twins recruited in the Genes in Myopia twin study, and subsequently provide direction for future studies into the aetiology of mono-chromatic aberrations. To our knowledge, the Genes in Myopia twin study is the first study to explore the role of genetic factors in both lower- and higher-order aberrations in a Caucasian population. Methods: Each individual completed a general questionnaire and underwent a comprehensive eye examination. Higher-order wavefront aberrations were calculated with Zernike coefficients up to the fourth order. Results: A total of 46 twin pairs with a mean age of 65.3 years were included in the analysis. Monozygotic intra-pair correlations were significantly higher compared to those in dizygotic twin pairs for defocus aberrations (p < 0.05). A trend for a genetic component was identified for higher-order aberrations. Conclusion: Genetic studies into refraction typically explore the genetic effects of lower- order aberrations such as myopia and hypermetropia; however, there is little to no research into the genetic basis of higher-order aberrations. The Genes in Myopia twin study indicates a potential genetic role for higher-order aberrations and provides useful insights into the aetiology of refractive error. Copyright (C) 2009 S. Karger AG, Basel