Tumor-infiltrating B cells come into vogue
Tumor-infiltrating B cells come into vogue
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DOI：
10.3748/wjg.v19.i1.8
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发表时间：
2013-01-07
影响因子：
4.3
通讯作者：
Linnebacher, Michael
中科院分区：
文献类型：
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作者：
Linnebacher, Michael
淋巴细胞浸润到实体瘤已被认为是积极预后的主要决定因素。在大多数情况下，这归因于能够直接破坏恶性细胞的细胞毒性T细胞。然而，当考虑到人类免疫系统的复杂组成时，Nielsen等人最近关于肿瘤浸润B细胞的潜在核心作用的发现并不令人惊讶。在这篇评论文章中，我想强调这一观察结果对基础和转化研究、预后程序以及最终对未来治疗概念的发展的巨大潜在影响。(C)2013年百世登。All rights reserved.
Lymphocyte infiltration into solid tumors has been recognized as a main determinator of positive prognosis. For the most part this is attributed to cytotoxic T cells capable of directly destroying malignant cells. However, when considering the complex composition of the human immune system, recent findings of Nielsen et al on a potentially central role of tumor-infiltrating B cells is not really surprising. In this commentary article, I want to highlight the enormous potential impact of this observation for basic and translational research, prognostic procedures and ultimately for the development of future therapeutic concepts. (C) 2013 Baishideng. All rights reserved.