Polymer-Based Restoration of Left Ventricular Mechanics
Polymer-Based Restoration of Left Ventricular Mechanics
复制标题
DOI：
10.3727/096368911x637461
复制
发表时间：
2013-01-01
影响因子：
3.3
通讯作者：
Sabbah, Hani N.
中科院分区：
文献类型：
--
作者：
Lee, Randall J.;Hinson, Andy;Sabbah, Hani N.
心力衰竭仍然是一个主要的医疗保健问题，对于严重晚期心力衰竭患者来说，选择相对较少。心力衰竭的标志是左心室进行性扩张，左心室壁变薄，导致壁应力增加和心肌耗氧量增加。将拉普拉斯定律应用于失败的扩张心室，左心室增强利用组织工程策略来增加壁厚并减小腔室直径，从而降低壁应力并改善左心室功能。综述了原位组织工程方法治疗心力衰竭的基本原理和Algisyl-LVR（TM）项目的早期临床结果。
Heart failure continues to be a major health care concern with relatively few options for severely advanced heart failure patients. The hallmark of heart failure is the progressive dilatation of the left ventricle, thinning of the left ventricular wall leading to increased wall stress and increased myocardial oxygen consumption. Applying Laplace's law to the failing dilated ventricle, left ventricular augmentation utilizes a tissue engineering strategy to increase wall thickness and reduce chamber diameter, resulting in a decrease in wall stress and improved left ventricular function. A review of the rationale for an in situ tissue engineering approach for this treatment of heart failure and early clinical results of the Algisyl-LVR (TM) program are presented.