Body Mass and White Matter Integrity: The Influence of Vascular and Inflammatory Markers
Body Mass and White Matter Integrity: The Influence of Vascular and Inflammatory Markers
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DOI：
10.1371/journal.pone.0077741
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发表时间：
2013-10-16
期刊：
影响因子：
3.7
通讯作者：
Kramer, Joel H.
中科院分区：
文献类型：
--
作者：
Bettcher, Brianne Magouirk;Walsh, Christine M.;Kramer, Joel H.
高肥胖与大脑健康密切相关，并且可能不成比例地影响白色物质完整性;然而，关于体重（BMI）和白色物质完整性之间相关性的机制的信息有限。本研究评估了血管和炎症标志物是否影响健康老龄化中BMI和白色物质之间的关系。我们对138名健康老年人（平均年龄：71.3岁）的白色完整性、BMI和血管/炎症因子进行了横断面评价。参与者接受了弥散张量成像，提供了血液样本，并参加了健康评估。评估了血管风险因素和血管/炎症血液标志物。主要结果测量是胼胝体、身体和压部（胼胝体）的各向异性分数（FA）;探索性测量包括额外的白色物质区域，基于与BMI的显著相关性。回归分析表明，较高的BMI与胼胝体、扣带回和穹窿中较低的FA相关（p
High adiposity is deleteriously associated with brain health, and may disproportionately affect white matter integrity; however, limited information exists regarding the mechanisms underlying the association between body mass (BMI) and white matter integrity. The present study evaluated whether vascular and inflammatory markers influence the relationship between BMI and white matter in healthy aging. We conducted a cross-sectional evaluation of white matter integrity, BMI, and vascular/inflammatory factors in a cohort of 138 healthy older adults (mean age: 71.3 years). Participants underwent diffusion tensor imaging, provided blood samples, and participated in a health evaluation. Vascular risk factors and vascular/inflammatory blood markers were assessed. The primary outcome measure was fractional anisotropy (FA) of the genu, body, and splenium (corpus callosum); exploratory measures included additional white matter regions, based on significant associations with BMI. Regression analyses indicated that higher BMI was associated with lower FA in the corpus callosum, cingulate, and fornix (p