Region-Specific Relationships Between Refractive Error and Ciliary Muscle Thickness in Children
Region-Specific Relationships Between Refractive Error and Ciliary Muscle Thickness in Children
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DOI：
10.1167/iovs.13-11658
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发表时间：
2013-07-01
影响因子：
4.4
通讯作者：
Bailey, Melissa D.
中科院分区：
文献类型：
--
作者：
Pucker, Andrew D.;Sinnott, Loraine T.;Bailey, Melissa D.
目的.目的探讨不同肌区睫状肌厚度与屈光不正的关系。使用眼前节光学相干断层扫描仪测量巩膜棘后1 mm（CMT 1）、2 mm（CMT 2）和3 mm（CMT 3）处的睫状肌麻痹厚度;还评估了最大厚度（CMTMAX）。使用自动验光仪测定睫状肌麻痹等效球镜屈光不正（SPHEQ）。通过从CMT 1和CMTMAX中减去相应的CMT 2值来获得心尖睫状肌纤维。多水平回归模型被用来确定肌肉和屈光不正的各个区域的睫状肌厚度之间的关系。受试者包括269名儿童，平均年龄为8.71 ± 1.51岁，平均屈光不正为+0.41 ± 1.29屈光度。在睫状肌厚度和SPHEQ的线性模型中，SPHEQ仅与CMT 2（β =-11.34，P = 0.0008）和CMT 3（β =-6.97，P = 0.007）显著相关。当CMT 1和CMTMAX减去相应的CMT 2值后，CMT 1（β = 14.75，P < 0.0001）和CMTMAX（β = 18.16，P < 0.0001）处的心尖纤维与SPHEQ有显著相关性。这些数据表明，在儿童中，近视眼（CMT 2和CMT 3）的后睫状肌纤维较厚，但矛盾的是，远视眼（CMTMAX和CMT 1）的顶端睫状肌纤维较厚。这可能是第一个证据表明，远视与较厚的顶端睫状肌区。
PURPOSE. To determine if there is a relationship between refractive error and ciliary muscle thickness in different muscle regions.METHODS. An anterior segment optical coherence tomographer was used to measure cycloplegic ciliary muscle thicknesses at 1 mm (CMT1), 2 mm (CMT2), and 3 mm (CMT3) posterior to the scleral spur; maximum (CMTMAX) thickness was also assessed. An autorefractor was used to determine cycloplegic spherical equivalent refractive error (SPHEQ). Apical ciliary muscle fibers were obtained by subtracting corresponding CMT2 values from CMT1 and CMTMAX. Multilevel regression models were used to determine the relationship between ciliary muscle thickness in various regions of the muscle and refractive error.RESULTS. Subjects included 269 children with a mean age of 8.71 +/- 1.51 years and a mean refractive error of +0.41 +/- 1.29 diopters. In linear models with ciliary muscle thicknesses and SPHEQ, SPHEQ was significantly associated only with CMT2 (beta = -11.34, P = 0.0008) and CMT 3 (beta = -6.97, P = 0.007). When corresponding values of CMT2 were subtracted from CMT1 and CMTMAX, apical fibers at CMT1 (beta = 14.75, P < 0.0001) and CMTMAX (beta = 18.16, P < 0.0001) had a significant relationship with SPHEQ.CONCLUSIONS. These data indicated that in children the posterior ciliary muscle fibers are thicker in myopia (CMT2 and CMT3), but paradoxically, the apical ciliary muscle fibers are thicker in hyperopia (CMTMAX and CMT1). This may be the first evidence that hyperopia is associated with a thicker apical ciliary muscle region.