Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men
Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men
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DOI：
10.1093/ajcn/82.2.309
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发表时间：
2005-08-01
影响因子：
7.1
通讯作者：
Bergeron, N
中科院分区：
文献类型：
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作者：
Desroches, S;Chouinard, PY;Bergeron, N
背景：膳食共轭亚油酸(CLA)已知可减少动脉粥样硬化、血浆总胆固醇和低密度脂蛋白-胆固醇浓度，以及几种动物体内脂肪的积累。在少数研究共轭亚油酸对人体影响的研究中，所有研究都使用由共轭亚油酸异构体混合物制成的商业配方的口服补充剂。目的：我们比较了在奶牛的日粮中添加葵花籽油和食用低共轭亚油酸的对照黄油(0.38克共轭亚油酸/100克黄油脂肪)对血浆脂蛋白和身体组成的影响。设计：在包括8周洗涤期的交叉设计研究中，男性16例[x+/-SD年龄：36.6+/-12.4岁；体重指数(以kg/m(2)为单位)：31.2+/-4.4]两种实验等能饲料各提供15%的能量为蛋白质，45%的能量为碳水化合物，40%的能量为脂肪，其中60%来自实验脂肪。血浆总胆固醇和总胆固醇/高密度脂蛋白比值(分别为-0.02和-0.00)的降幅均小于辅酶B饮食(分别为-0.26和-0.34)。计算机断层扫描测量的腹部脂肪组织面积显示，在两种实验饮食后，内脏脂肪组织和皮下脂肪组织的积累没有差异。结论：这些结果表明，黄油脂肪增加10倍并不会对超重或肥胖男性产生有益的代谢影响。
Background: Dietary conjugated linoleic acid (CLA) is known to reduce atherosclerosis, plasma total and LDL-cholesterol concentrations, and body fat accumulation in several animal species. Of the few studies that investigated the effects of CLA supplementation in humans, all used commercially formulated oral supplements made from a mixture of CLA isomers.Objective: We compared the effects on plasma lipoproteins and body composition of the consumption of a modified butter naturally enriched with CLA (CLA-B: 4.22 g CLA/100 g butter fat) by the addition of sunflower oil to the diet of dairy cows with the consumption of a control butter (CON-B) that was low in CLA (0.38 g CLA/100 g butter fat).Design: In a crossover design study including an 8-wk washout period, 16 men [x +/- SD age: 36.6 +/- 12.4 y; body mass index (in kg/m(2)): 31.2 +/- 4.4] were fed each of the 2 experimental isoenergetic diets, providing 15% of energy as protein, 45% as carbohydrates, and 40% as lipids, of which > 60% was derived from experimental fats, for 4 wk.Results: Consumption of the CLA-B diet induced a significantly (P < 0.05) smaller reduction in plasma total cholesterol and in the ratio of total to HDL cholesterol (-0.02 mmol/L and -0.00, respectively) than did consumption of the CON-B diet (-0.26 mmol/L and -0.34, respectively). Abdominal adipose tissue area measured by computed tomography showed no difference in accumulation of either visceral or subcutaneous adipose tissue after the 2 experimental diets.Conclusion: These results suggest that a 10-fold CLA enrichment of butter fat does not induce beneficial metabolic effects in overweight or obese men.