A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: dose-response analysis of thyroid follicular adenomas detected during first screening in Ukraine (1998-2000).
A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: dose-response analysis of thyroid follicular adenomas detected during first screening in Ukraine (1998-2000).
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切尔诺贝利事故后甲状腺癌和其他甲状腺疾病的队列研究：乌克兰首次筛查期间检测到的甲状腺滤泡腺瘤的剂量反应分析（1998-2000）。
DOI：
10.1093/aje/kwm301
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发表时间：
2008
影响因子：
5
通讯作者：
Terekhova,Galina
中科院分区：
文献类型：
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作者：
Zablotska,LydiaB;Bogdanova,TetyanaI;Ron,Elaine;Epstein,OvsiyV;Robbins,Jacob;Likhtarev,IllyaA;Hatch,Maureen;Markov,ValentynV;Bouville,AndreC;Olijnyk,ValeryA;McConnell,RobertJ;Shpak,VictorM;Brenner,Alina;Terekhova,Galina
1986 年的切尔诺贝利事故使许多人暴露于放射性碘，主要是 131I，其对良性甲状腺疾病的影响在很大程度上尚不清楚。为了调查切尔诺贝利事故后与辐射剂量相关的滤泡腺瘤的风险，作者分析了一项针对儿童或青少年时受到辐射的前瞻性筛查队列研究的基线数据。分层随机样本是从所有年龄小于 18 岁、事故发生后 2 个月内进行过甲状腺放射性测量、居住在乌克兰三个重度污染地区的个体中抽取的。该分析基于 12,504 名已知甲状腺疾病个人史的受试者中诊断出的 23 例病例。剂量-反应关系呈线性，超额相对风险为每格雷 2.07（95% 置信区间：0.28、10.31）。与男性相比，女性的风险明显更高，暴露年龄没有明显的改变影响。总之，儿童和青少年时期接触放射性碘的人患滤泡性腺瘤的风险增加，尽管其风险低于同一人群中患甲状腺癌的风险。与其他研究的结果相比，这一估计值稍小，但置信区间重叠，表明兼容性。
The Chornobyl (Chernobyl) accident in 1986 exposed many individuals to radioactive iodines, chiefly131I, the effects of which on benign thyroid diseases are largely unknown. To investigate the risk of follicular adenoma in relation to radiation dose after Chornobyl, the authors analyzed the baseline data from a prospective screening cohort study of those exposed as children or adolescents. A stratified random sample was selected from all individuals who were younger than 18 years, had thyroid radioactivity measurements taken within 2 months after the accident, and resided in the three heavily contaminated areas in Ukraine. This analysis is based on the 23 cases diagnosed in 12,504 subjects for whom personal history of thyroid diseases was known. The dose-response relation was linear with an excess relative risk of 2.07 per gray (95% confidence interval: 0.28, 10.31). The risk was significantly higher in women compared with men, with no clear modifying effects of age at exposure. In conclusion, persons exposed to radioactive iodines as children and adolescents have an increased risk of follicular adenoma, though it is smaller than the risk of thyroid cancer in the same cohort. Compared with results from other studies, this estimate is somewhat smaller, but confidence intervals overlap, suggesting compatibility.