Primary central nervous system lymphoma: A curable disease
Primary central nervous system lymphoma: A curable disease
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DOI：
10.1002/hon.2598
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发表时间：
2019-06-01
影响因子：
3.3
通讯作者：
Batchelor, Tracy T.
中科院分区：
文献类型：
--
作者：
Batchelor, Tracy T.
原发性中枢神经系统淋巴瘤是一种罕见的非霍奇金淋巴瘤亚型，局限于脑、软脑膜或眼，与其他淋巴结弥漫性大B细胞淋巴瘤相比，预后相对较差。然而，以甲氨蝶呤为基础的诱导化疗，随后是巩固化疗或高剂量治疗和自体干细胞移植，与生存率提高和神经毒性降低相关。B细胞受体信号传导的异常激活和核因子κ β的激活是一种常见的遗传改变，并为这种淋巴瘤亚型的靶向治疗提供了机会。
Primary central nervous system lymphoma is a rare subtype of non-Hodgkin lymphoma that is confined to the brain, leptomeninges, or the eye and is associated with a relatively poor prognosis compared to other extranodal diffuse large B-cell lymphomas. However, methotrexate-based induction chemotherapy followed by consolidative chemotherapy or high-dose therapy and autologous stem cell transplantation is associated with improved survival and reduced neurotoxicity. Aberrant activation of B-cell receptor signaling and activation of nuclear factor kappa beta is a frequent genetic alteration and offers opportunities for targeted therapies in this lymphoma subtype.