Platelet aggregation in the formation of tumor metastasis.
Platelet aggregation in the formation of tumor metastasis.
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DOI：
10.2183/pjab.84.189
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Fujita N
中科院分区：
文献类型：
--
作者：
Tsuruo T;Fujita N
转移是癌症死亡的主要原因，但针对它的最佳策略仍然不确定。血行转移的发病机制是动态的，由以下步骤组成：1）肿瘤细胞从原发部位脱离，2）侵入宿主血管，3）在宿主血流中迁移，4）沿循环沿着运输，5）在远端器官中的毛细血管中停滞或粘附，6）外渗，以及7）在外来组织内增殖。成功的血行转移的关键是肿瘤在血流中的存活，因为大多数循环肿瘤细胞被剪切力迅速破坏或被免疫系统攻击。这些细胞中不到0.01%导致转移。据报道，肿瘤细胞诱导的血小板聚集通过增加微循环中肿瘤细胞栓子的阻滞而促进血行转移。血小板聚集也被认为保护肿瘤细胞免受循环中的免疫攻击。我们已经确定Aggrus是一种血小板聚集因子，在许多人类癌症中表达。由于当中和抗体或消除碳水化合物减弱Aggrus功能时，血行转移减少，因此Aggrus对表达Aggrus的细胞的血行转移的主要贡献是通过促进血小板聚集。Aggrus可以作为药物开发的理想靶点来阻断转移。
Metastasis is the major cause of death from cancer, yet the optimal strategy against it remains uncertain. The pathogenesis of hematogenous metastasis is dynamic and consists of the following steps: 1) detachment of tumor cells from the primary site, 2) invasion into the host’s blood vessels, 3) migration in the host’s blood stream, 4) transport along the circulation, 5) arrest in or adhesion to the capillary in a distant organ, 6) extravasation, and 7) proliferation within the foreign tissues. A key to successful hematogenous metastasis is tumor survival in the bloodstream because most circulating tumor cells are rapidly destroyed by the shear forces or are attacked by the immune system. Less than 0.01% of these cells result in metastasis. Tumor cell–induced platelet aggregation has been reported to facilitate hematogenous metastasis by increasing the arrest of tumor cell emboli in the microcirculation. Platelet aggregation is also believed to protect tumor cells from immunological assault in the circulation. We have identified Aggrus as a platelet–aggregating factor expressed on a number of human cancers. Because hematogenous metastasis is reduced when neutralizing antibodies or eliminating carbohydrates attenuates Aggrus function, Aggrus’s main contribution to hematogenous metastasis of Aggrus–expressing cells, then, is by promoting platelet aggregation. Aggrus could serve as an ideal target for drug development to block metastasis.
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影响因子：
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