Use of long-acting somatostatin analog SMS 201-995 in patients with pancreatic islet cell tumors
Use of long-acting somatostatin analog SMS 201-995 in patients with pancreatic islet cell tumors
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长效生长抑素类似物 SMS 201-995 在胰岛细胞肿瘤患者中的应用
DOI：
10.1007/bf01536043
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发表时间：
1989
影响因子：
3.1
通讯作者：
R. Jensen
中科院分区：
文献类型：
--
作者：
P. Maton;J. Gardner;R. Jensen
天然生长抑素可降低许多肽的血浆浓度，对胰岛细胞瘤患者有短期疗效，但必须持续静脉输注。我们回顾了已发表的长效合成生长抑素类似物SMS 201-995治疗胰岛细胞瘤患者的经验。15/18例血管活性肠肽生成性肿瘤患者、8/8例胰高血糖素瘤患者、7/7例不可切除胰岛素瘤患者和3/3例生长激素释放因子生成性肿瘤患者对SMS 201-995有良好的持续症状反应。良性胰岛素瘤患者反应迅速，最好通过手术治疗。胃泌素瘤患者最好口服胃抗分泌剂治疗。在所有这些综合征中，对SMS 201-995的临床反应不一定与标记肽的血浆浓度的变化平行，这表明SMS 201-995可能在各个部位具有作用。在46名患者中评估了SMS 201-995对肿瘤大小的影响，其中不到20%的患者显示肿瘤大小减小。副作用轻微，但包括脂肪和胃肠道紊乱。需要更多的研究来充分评估SMS 201-995长期给药的效果。
Natural somatostatin reduces plasma concentrations of many peptides, and is of short term benefit in patients with islet cell tumors, but has to be given as a continuous intravenous infusion. We review the published experience with the long acting synthetic somatostatin analogue SMS 201-995 in patients with islet cell tumors. Fifteen of 18 patients with vasoactive intestinal peptide-producing tumors, 8 of 8 patients with glucagonomas, 7 of 7 patients with unresectable insulinomas, and 3 of 3 patients with growth hormone releasing factor-producing tumors had a good sustained symptomatic response to SMS 201-995. Patients with benign insulinomas responded variably and are best treated by surgery. Patients with gastrinomas are best treated by oral gastric antisecretory agents. In all these syndromes, the clinical response to SMS 201-995 did not necessarily parallel the change in plasma concentration of marker peptide, suggesting that SMS 201-995 may have actions at various sites. The effect of SMS 201-995 on tumor size has been assessed in 46 patients, less than 20% of whom showed a reduction in tumor size. Side effects have been mild, but include steatorrhea and gastrointestinal disturbances. More studies will be required to fully assess the effects of longterm administration of SMS 201-995.
胰腺霍乱综合征：合成生长抑素类似物对肠道水和离子运输的影响。
影响因子：
39.2
作者：
Santangelo,WC;O'Dorisio,TM;Kim,JG;Severino,G;Krejs,GJ
通讯作者：
Krejs,GJ
生长抑素类似物 SMS 201-995 可减少患有分泌生长激素释放因子的胰岛细胞瘤患者的垂体大小。
DOI：
10.1530/acta.0.1130023
发表时间：
1986
期刊：
Acta endocrinologica
影响因子：
--
作者：
Wilson,DM;Hoffman,AR
通讯作者：
Hoffman,AR