Dietary Folate and Vitamin B6 and B12 Intake in Relation to Mortality From Cardiovascular Diseases Japan Collaborative Cohort Study
Dietary Folate and Vitamin B6 and B12 Intake in Relation to Mortality From Cardiovascular Diseases Japan Collaborative Cohort Study
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DOI：
10.1161/strokeaha.110.578906
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发表时间：
2010-06-01
期刊：
影响因子：
8.3
通讯作者：
Tamakoshi, Akiko
中科院分区：
文献类型：
--
作者：
Cui, Renzhe;Iso, Hiroyasu;Tamakoshi, Akiko
背景和目的：膳食中叶酸和B族维生素摄入量与心血管疾病风险的关系存在争议，在亚洲人群中的证据有限。方法：在日本合作队列研究中，共有23 119名男性和35 611名女性，年龄在40至79岁之间，完成了食物频率调查问卷。在平均14年的随访期间，有986人死于中风，424人死于冠心病，2087人死于心血管疾病。结果：饮食中叶酸和维生素B-6的摄入量与男性心力衰竭死亡率呈负相关，与女性中风、冠心病和心血管疾病死亡率呈负相关。在调整心血管危险因素后，这些负相关关系没有实质性改变。没有发现维生素B-12摄入量与死亡风险之间的联系。结论：在日本，高叶酸和维生素B-6的膳食摄入量与中风、冠心病和心力衰竭的死亡率降低有关。（中风。2010;41:1285-1289）
Background and Purpose-The association of dietary folate and B vitamin intakes with risk of cardiovascular disease is controversial, and the evidence in Asian populations is limited.Methods-A total of 23 119 men and 35 611 women, age 40 to 79 years, completed a food frequency questionnaire in the Japan Collaborative Cohort Study. During the median 14-year follow-up, there were 986 deaths from stroke, 424 from coronary heart disease, and 2087 from cardiovascular disease.Results-Dietary folate and vitamin B-6 intakes were inversely associated with mortality from heart failure for men and with mortality from stroke, coronary heart disease, and total cardiovascular disease for women. These inverse associations did not change materially after adjustment for cardiovascular risk factors. No association was found between vitamin B-12 intake and mortality risk.Conclusions-High dietary intakes of folate and vitamin B-6 were associated with reduced risk of mortality from stroke, coronary heart disease, and heart failure among Japanese. (Stroke. 2010; 41:1285-1289.)