Prenatal determinants of schizophrenia: what we have learned thus far?

Prenatal determinants of schizophrenia: what we have learned thus far?
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DOI：
10.1017/s1121189x00007946
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发表时间：
2005-10-01
期刊：
EPIDEMIOLOGIA E PSICHIATRIA SOCIALE-AN INTERNATIONAL JOURNAL FOR EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
影响因子：
--
通讯作者：
Susser, ES
Susser, ES
中科院分区：
其他
文献类型：
--
作者：
Bresnahan, M;Schaefer, CA;Susser, ES

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精神分裂症的产前决定因素（PDS）研究旨在检查精神分裂症的早期前因。基于1959年至1967年收集的儿童健康与发展研究队列，超过12，000名队列成员在PDS研究中接受了精神疾病的随访。使用广泛的数据和生物样本前瞻性收集在怀孕期间开始，PDS研究人员已经检查了产前暴露对成年期精神分裂症风险的影响。在这里，我们描述了一些关键的发现，从PDS方面产前感染，营养和有毒物质的暴露。
The Prenatal Determinants of Schizophrenia (PDS) study was designed to examine early antecedents to schizophrenia. Based in the Child Health and Development Study cohort assembled in 1959-1967, over 12,000 cohort members were followed in the PDS study for psychiatric disorders. Using the extensive data and biological samples prospectively collected beginning during pregnancy, PDS investigators have examined the influence of prenatal exposures on risk of schizophrenia in adulthood. Here we describe a few key findings from the PDS with respect to prenatal infection, nutrition, and toxic exposures.