Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit
Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit
复制标题
DOI：
10.1093/nar/28.17.3185
复制
发表时间：
2000-09-01
影响因子：
14.9
通讯作者：
Atkins, JF
中科院分区：
文献类型：
--
作者：
Ivanov, IP;Gesteland, RF;Atkins, JF
程序化核糖体移码在解码抗酶mRNA中的效率是控制从酵母裂殖酵母到果蝇到哺乳动物的生物体中的细胞多胺水平的自动调节回路的传感器。在许多生物体中的移码位点和侧翼刺激信号的比较，现在允许重建的可能的进化路径的显着保守的mRNA序列参与移码。
The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting.