Pooling analysis reveals that galectin-1 is a reliable prognostic biomarker in various cancers
Pooling analysis reveals that galectin-1 is a reliable prognostic biomarker in various cancers
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汇集分析表明，galectin-1 是多种癌症的可靠预后生物标志物
DOI：
10.1002/jcp.28059
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发表时间：
2019-08-01
影响因子：
5.6
通讯作者：
Liu, Ji-Long
中科院分区：
文献类型：
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作者：
Huang, Ming-Yu;He, Jia-Peng;Liu, Ji-Long
据报道，半乳糖凝集素-1在各种人类癌症中上调。然而，半乳糖凝集素-1表达与癌症预后之间的关系尚未得到系统评估。在本研究中，我们检索了PubMed、Web of Science和Embase，以收集所有相关研究，并进行了荟萃分析。我们发现半乳糖凝集素-1表达的增加与肿瘤大小（比值比[OR]=1.75; 95%可信区间[CI]：1.06-2.89; p=0.029）、临床分期（OR=3.89; 95% CI：2.40 - 6.31; p=0.029）、肿瘤大小（OR = 1.75; 95%可信区间[CI]：1.06- 2.89; p=0.029）、临床分期（OR=3.89; 95% CI：2.40-6.31; p = 0.029）、肿瘤大小（OR = 1.75; 95%可信区间[CI]：1.06 - 2.89; p = 0.029）、临床分期（OR= 3.89; 95%可信区间[CI]：2.40 -6.31; p = 0.029）有关。
Galectin-1 is reported to be upregulated in various human cancers. However, the relationship between galectin-1 expression and cancer prognosis has not been systematically assessed. In this study, we searched PubMed, Web of Science, and Embase to collect all relevant studies and a meta-analysis was performed. We found that increased galectin-1 expression was associated with tumor size (odds ratio [OR]=1.75; 95% confidence interval [CI]: 1.06-2.89; p=0.029), clinical stage (OR=3.89; 95% CI: 2.40-6.31; p