Origins of bilateral symmetry:: Hox and dpp expression in a sea anemone
Origins of bilateral symmetry:: Hox and dpp expression in a sea anemone
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DOI：
10.1126/science.1091946
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发表时间：
2004-05-28
期刊：
影响因子：
56.9
通讯作者：
Martindale, MQ
中科院分区：
文献类型：
--
作者：
Finnerty, JR;Pang, K;Martindale, MQ
超过99%的现代动物是进化谱系Bilateria的成员。两侧对称性的起源部分地归功于两侧对称性的进化成功。虽然刺胞动物门的动物不属于两侧动物门，但一些代表性的动物，如海葵Nematostella vectensis，表现出两侧对称性。我们发现，Nematostella使用同源基因，以实现双边对称：多个Hox基因的表达在一个交错的方式沿着其主要的身体轴，和转化生长因子β基因decapentaplegic（DPP）的表达在一个不对称的方式约其次要的身体轴。这些数据表明，双边对称出现之前，刺胞动物和Bilateria的进化分裂。
Over 99% of modern animals are members of the evolutionary lineage Bilateria. The evolutionary success of Bilateria is credited partly to the origin of bilateral symmetry. Although animals of the phylum Cnidaria are not within the Bilateria, some representatives, such as the sea anemone Nematostella vectensis, exhibit bilateral symmetry. We show that Nematostella uses homologous genes to achieve bilateral symmetry: Multiple Hox genes are expressed in a staggered fashion along its primary body axis, and the transforming growth factor-beta gene decapentaplegic (dpp) is expressed in an asymmetric fashion about its secondary body axis. These data suggest that bilateral symmetry arose before the evolutionary split of Cnidaria and Bilateria.