Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B.
Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B.
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DOI：
10.1002/hep.29479
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Guo H
中科院分区：
文献类型：
--
作者：
Hong X;Kim ES;Guo H
乙肝病毒感染是世界范围内严重的公共卫生负担。虽然目前的治疗方法设法控制了疾病的进展，但需要终身治疗和监测，因为在治疗过程中会产生抗药性，而且在停药后经常会出现重新激活的情况。因此，肝细胞癌(HCC)的发生减少了，但并未消除。治疗失败的一个主要原因是无法根除或灭活病毒共价闭合环状DNA(CccDNA)，它是一种稳定的上体形式的病毒基因组，上面装饰着宿主组蛋白和非组蛋白。越来越多的证据表明，cccDNA的表观遗传修饰有助于病毒复制和慢性乙肝病毒感染的结局。本文通过借鉴表观遗传学治疗癌症和其他病毒性疾病的方法，综述了表观遗传学的研究进展及其对慢性乙肝的治疗意义，为慢性乙型肝炎的治疗开辟了新的途径。
Hepatitis B virus (HBV) infection represents a significant public health burden worldwide. Although current therapeutics manage to control the disease progression, lifelong treatment and surveillance are required because drug resistance develops during treatment and reactivations frequently occur following medication cessation. Thus, the occurrence of hepatocellular carcinoma (HCC) is decreased but not eliminated. One major reason for the treatment failure is the inability to eradicate or inactivate the viral covalently closed circular DNA (cccDNA) which is a stable episomal form of viral genome decorated with host histones and non-histone proteins. Accumulating evidence suggests that epigenetic modifications of cccDNA contribute to viral replication and the outcome of chronic HBV infection. Here, we summarize the progress on HBV epigenetics research and the therapeutic implications for chronic HBV infection by learning from the epigenetic therapies for cancer and other viral diseases, which may open a new venue to cure the chronic hepatitis B.
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