Altered mesolimbocortical and thalamic dopamine in Tourette syndrome
Altered mesolimbocortical and thalamic dopamine in Tourette syndrome
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DOI：
10.1212/01.wnl.0000242733.18534.2c
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发表时间：
2006-11-14
期刊：
影响因子：
9.9
通讯作者：
Sallee, F. R.
中科院分区：
文献类型：
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作者：
Gilbert, D. L.;Christian, B. T.;Sallee, F. R.
我们在6名患有多发性抽动症的成年人和年龄匹配的对照组中使用了[F-18]FolyPride PET来评估纹状体外多巴胺2(D2)受体。D2受体在眼眶前额叶皮质、初级运动皮质、扣带回前回、丘脑内侧背侧核和海马区显著降低，这些区域对动机和奖励、感觉门控、运动和注意力都很重要。中脑皮质系统和丘脑的多巴胺能功能改变可能有助于增加抽动的动机突显性。
We used [F-18] fallypride PET in six adults with Tourette syndrome and age-matched controls to assess extrastriatal dopamine 2 (D2) receptors. D2 receptor availability was significantly lower in the orbitofrontal cortex, primary motor cortex, anterior cingulate gyrus, mediodorsal nucleus of thalamus, and hippocampus, areas important for motivation and reward, sensory gating, movement, and attention. Altered dopaminergic function in mesolimbocortical systems and thalamus may contribute to increased motivational salience of tics.