NEURONAL ACTIVITY PATTERNS IN THE DEVELOPING BARREL CORTEX
NEURONAL ACTIVITY PATTERNS IN THE DEVELOPING BARREL CORTEX
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DOI：
10.1016/j.neuroscience.2017.05.025
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发表时间：
2018-01-01
期刊：
影响因子：
3.3
通讯作者：
Khazipov, Rustem
中科院分区：
文献类型：
--
作者：
Luhmann, Heiko J.;Khazipov, Rustem
发育中的桶状皮质揭示了丰富的神经元活动模式，这些模式也在其他感觉新皮质区和其他物种中发现，包括早产儿的体感皮质。最早的阶段的特征是异步的，稀疏的单细胞在低频率下放电。在第二阶段，神经元表现出相关放电，其最初由电突触介导，随后转化为依赖于化学突触的网络爆发。在第二阶段的活动模式是同步高原组装，三角洲波，纺锤爆发和早期伽马振荡（EGO）。在新生的啮齿类动物中，纺锤体爆发和EGO自发地发生，或者可以通过感官刺激引起，并在出生当天将桶相关柱状网络中的活动与地形组织同步。干扰这种早期活动会导致皮质结构发展的紊乱，这表明纺锤体爆发和EGO影响皮质柱的形成。早期神经元活动也控制着发育中的桶状皮质中程序性细胞死亡的速率，这表明纺锤体爆发和EGO是特别适合于抑制细胞凋亡的生理活动模式。这些不同的新皮层活动模式如何控制早期发育过程，如突触、微电路、地形图和大规模网络的形成，还有待于更详细的研究。本文是特刊的一部分，题为：桶皮质。(C)2017年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The developing barrel cortex reveals a rich repertoire of neuronal activity patterns, which have been also found in other sensory neocortical areas and in other species including the somatosensory cortex of preterm human infants. The earliest stage is characterized by asynchronous, sparse single-cell firing at low frequencies. During the second stage neurons show correlated firing, which is initially mediated by electrical synapses and subsequently transforms into network bursts depending on chemical synapses. Activity patterns during this second stage are synchronous plateau assemblies, delta waves, spindle bursts and early gamma oscillations (EGOs). In newborn rodents spindle bursts and EGOs occur spontaneously or can be elicited by sensory stimulation and synchronize the activity in a barrel-related columnar network with topographic organization at the day of birth. Interfering with this early activity causes a disturbance in the development of the cortical architecture, indicating that spindle bursts and EGOs influence the formation of cortical columns. Early neuronal activity also controls the rate of programed cell death in the developing barrel cortex, suggesting that spindle bursts and EGOs are physiological activity patterns particularly suited to suppress apoptosis. It remains to be studied in more detail how these different neocortical activity patterns control early developmental processes such as formation of synapses, microcircuits, topographic maps and large-scale networks. This article is part of a Special Issue entitled: Barrel Cortex. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.