The visual white matter connecting human area prostriata and the thalamus is retinotopically organized
The visual white matter connecting human area prostriata and the thalamus is retinotopically organized
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DOI：
10.1007/s00429-020-02096-5
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发表时间：
2020-06-13
影响因子：
3.1
通讯作者：
Pestilli, Franco
中科院分区：
文献类型：
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作者：
Kurzawski, Jan W.;Mikellidou, Kyriaki;Pestilli, Franco
人类的视觉系统能够处理从中心凹到远周边视野的视觉信息。最近的功能磁共振成像研究显示了完整而详细的前额纹区视网膜定位图，位于顶枕沟腹背部和距骨沟前面，强烈倾向于外周和宽视野刺激。在这里，我们报告了白质连接的解剖模式之间的前额纹状体和丘脑周围的外侧膝状体核(LGN)。为此，我们开发并利用了由一系列开放运行在云计算平台Brainlife上的应用程序组成的自动化管道来分析139个人类连接项目(HCP)的主题。我们观察到一束连续的延伸的白质纤维束，从中可以提取出两个亚成分：一个平行于视神经辐射通过腹侧，另一个从背侧绕过侧脑室。有趣的是，背侧运动的环连接丘脑和位于前部的前额叶的中央视野，而另一个运动更靠腹的环连接LGN和位于后方的更外围的视野表示。然后，我们分析了另外10名HCP受试者，使用脑部外的手动平面提取方法来研究提取的两个白质亚成分与前纹状体内的偏心率、髓鞘和皮质厚度梯度的关系。我们的结果与最近在OR中展示的视网膜原位分离是一致的，在人类中连接LGN和V1，并首次揭示了关于丘脑和关联视区之间的纤维束的轨迹的视网膜原位分离。
The human visual system is capable of processing visual information from fovea to the far peripheral visual field. Recent fMRI studies have shown a full and detailed retinotopic map in area prostriata, located ventro-dorsally and anterior to the calcarine sulcus along the parieto-occipital sulcus with strong preference for peripheral and wide-field stimulation. Here, we report the anatomical pattern of white matter connections between area prostriata and the thalamus encompassing the lateral geniculate nucleus (LGN). To this end, we developed and utilized an automated pipeline comprising a series of Apps that run openly on the cloud computing platform brainlife.io to analyse 139 subjects of the Human Connectome Project (HCP). We observe a continuous and extended bundle of white matter fibers from which two subcomponents can be extracted: one passing ventrally parallel to the optic radiations (OR) and another passing dorsally circumventing the lateral ventricle. Interestingly, the loop travelling dorsally connects the thalamus with the central visual field representation of prostriata located anteriorly, while the other loop travelling more ventrally connects the LGN with the more peripheral visual field representation located posteriorly. We then analyse an additional cohort of 10 HCP subjects using a manual plane extraction method outside brainlife.io to study the relationship between the two extracted white matter subcomponents and eccentricity, myelin and cortical thickness gradients within prostriata. Our results are consistent with a retinotopic segregation recently demonstrated in the OR, connecting the LGN and V1 in humans and reveal for the first time a retinotopic segregation regarding the trajectory of a fiber bundle between the thalamus and an associative visual area.