Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography
Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography
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DOI：
10.1117/1.jbo.18.12.121509
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发表时间：
2013-12-01
影响因子：
3.5
通讯作者：
Wang, Ruikang K.
中科院分区：
文献类型：
--
作者：
Song, Shaozhen;Huang, Zhihong;Wang, Ruikang K.
我们提出了一个综合的方法相结合的低频力学与光学成像映射的剪切模量内的生物组织。利用相位敏感光学相干层析成像技术（PhS-OCT）对在组织中传播的剪切波进行了时空跟踪。从跟踪结果获得的剪切波速的局部估计可以映射局部剪切模量。PhS-OCT系统以类似于47 kHz的等效帧速率远程记录深度分辨的动态机械波，具有高空间分辨率。通过检测由琼脂和光散射材料制成的仿组织模型，验证了所提出的方法。结果表明，剪切波成像可以准确地映射这些幻影的弹性模量。(C)2013年，美国光电仪器工程师学会（SPIE）
We propose an integrated method combining low-frequency mechanics with optical imaging to map the shear modulus within the biological tissue. Induced shear wave propagating in tissue is tracked in space and time using phase-sensitive optical coherence tomography (PhS-OCT). Local estimates of the shear-wave speed obtained from tracking results can image the local shear modulus. A PhS-OCT system remotely records depth-resolved, dynamic mechanical waves at an equivalent frame rate of similar to 47 kHz with the high spatial resolution. The proposed method was validated by examining tissue-mimicking phantoms made of agar and light scattering material. Results demonstrate that the shear wave imaging can accurately map the elastic moduli of these phantoms. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)