α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice
α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice
复制标题
a-Mangostin 重塑内脏脂肪组织炎症，改善小鼠与年龄相关的代谢紊乱
DOI：
10.18632/aging.102512
复制
发表时间：
2019-12-15
期刊：
影响因子：
5.2
通讯作者：
Lin, Ligen
中科院分区：
文献类型：
--
作者：
Li, Dan;Liu, Qianyu;Lin, Ligen
Low-grade chronic adipose tissue inflammation contributes to the onset and development of aging-related insulin resistance and type 2 diabetes. In the current study, alpha-mangostin, a xanthone isolated from mangosteen (Garcinia mangastana), was identified to ameliorate lipopolysaccharides-induced acute adipose tissue inflammation in mice, by reducing the expression of pro-inflammatory cytokines and chemokines. In a cohort of young (3 months) and old (18-20 months) mice, alpha-mangostin mitigated aging-associated adiposity, hyperlipidemia, and insulin resistance. Further study showed that alpha-mangostin alleviated aging-related adipose tissue inflammation by reducing macrophage content and shifting pro-inflammatory macrophage polarization. Moreover, alpha-mangostin protected the old mice against liver injury through suppressing the secretion of microRNA-155-5p from macrophages. The above results demonstrated that alpha-mangostin represents a new scaffold to alleviate adipose tissue inflammation, which might be a novel candidate to treat aging-related metabolic disorders.
