Central Role of α-Synuclein Oligomers in Neurodegeneration in Parkinson Disease
Central Role of α-Synuclein Oligomers in Neurodegeneration in Parkinson Disease
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DOI：
10.1001/archneur.65.12.1577
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发表时间：
2008-12-01
影响因子：
--
通讯作者：
Kolchinsky, Alexander M.
中科院分区：
文献类型：
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作者：
Kazantsev, Aleksey G.;Kolchinsky, Alexander M.
黑质纹状体神经元的选择性死亡导致帕金森病，这是由脑蛋白α-突触核蛋白的错误折叠解释的。在此，我们回顾了支持这一概念的数据，提出了一个计划的事件导致突触核蛋白诱导的神经元死亡，并讨论蛋白脱乙酰酶sirtuins作为新的潜在的治疗目标参与这一过程。
Selective death of nigrostriatal neurons, which leads to Parkinson disease, is explained by misfolding of brain protein alpha-synuclein. Herein, we review the data supporting this concept, propose a scheme of events leading to synuclein-induced neuronal death, and discuss protein deacetylase sirtuins as new potential therapeutic targets involved in this process.