Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila
Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila
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DOI：
10.1016/s0092-8674(01)00607-9
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发表时间：
2001-12-28
期刊：
影响因子：
64.5
通讯作者：
Montell, DJ
中科院分区：
文献类型：
--
作者：
Silver, DL;Montell, DJ
JAK/STAT信号通路以其对细胞增殖和存活的影响而闻名，在包括卵巢癌在内的各种人类癌症中具有组成性活性。我们已经发现，JAK和STAT是将果蝇卵巢中的边缘细胞从静止的上皮细胞转化为迁移的侵袭细胞所必需的。该途径的配体，未配对（UPD），由迁移细胞簇内的两个中心细胞表达。upd或jak的突变导致迁移缺陷和聚集细胞数量的减少。UPD或JAK的异位表达足以诱导额外的上皮细胞迁移。因此，局部信号激活邻近上皮细胞中的JAK/ STAT通路，导致它们变得具有侵袭性。
The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive cells. The ligand for this pathway, Unpaired (UPD), is expressed by two central cells within the migratory cell cluster. Mutations in upd or jak cause defects in migration and a reduction in the number of cells recruited to the cluster. Ectopic expression of either UPD or JAK is sufficient to induce extra epithelial cells to migrate. Thus, a localized signal activates the JAK/ STAT pathway in neighboring epithelial cells, causing them to become invasive.