Pregnancy outcomes in women with different doses of corticosteroid supplementation during labor and delivery
Pregnancy outcomes in women with different doses of corticosteroid supplementation during labor and delivery
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临产和分娩期间补充不同剂量皮质类固醇的妇女的妊娠结局
DOI：
10.1111/jog.13336
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
T.
中科院分区：
文献类型：
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作者：
Owa;T. Mimura;K. Kakigano;A. Matsuzaki;S. Kumasawa;K. Endo;M. Tomimatsu;T. Kimura;T.
AimThe的目的是本研究的目的是报告妊娠结局的妇女谁收到不同剂量的皮质类固醇补充剂在劳动力和deliver.MethodsWe进行了回顾性分析，102名孕妇谁收到口服皮质类固醇治疗，在大坂大学医院交付，并在劳动力和分娩过程中给予静脉皮质类固醇补充。从2008年1月至2012年5月，47名女性接受了高剂量皮质类固醇（HD组）。从2012年6月至2016年12月，55名妇女给予低剂量皮质类固醇（LD组）。最常见的疾病是系统性红斑狼疮（30/102; 29.4%）。大多数妇女使用泼尼松龙超过1年（91/102; 89.2%），剂量超过5 mg/天（88/102; 86.3%）。分娩和分娩期间氢化可的松的总静脉剂量±标准差为233.5 ± 129.4 mg（HD组）和143.4 ± 38.1 mg（LD组），HD组的剂量显著更大。没有患者出现肾上腺功能不全，血流动力学也没有显著差异。HD组中有3例产后尿道炎，2例高血糖症和1例伤口感染，而LD组中有1例产后尿道炎。新生儿outcomes.ConclusionPregnancy的结果没有显着差异之间的高剂量和低剂量的皮质类固醇补充剂在劳动和分娩。
AimThe aim of this study was to report the pregnancy outcomes of women who received different doses of corticosteroid supplementation during labor and delivery.MethodsWe conducted a retrospective review of 102 pregnant women who received oral corticosteroid therapy, delivered at Osaka University Hospital, and were administered intravenous corticosteroid supplementation during labor and delivery. From January 2008 to May 2012, 47 women were administered a high dose of corticosteroids (HD group). From June 2012 to December 2016, 55 women were given a low dose of corticosteroids (LD group).ResultsThere were no significant differences in the patient characteristics between the two groups. The most frequent disease was systemic lupus erythematosus (30/102; 29.4%). Most women used prednisolone for more than 1 year (91/102; 89.2%) and at a dose of more than 5 mg/day (88/102; 86.3%). The total intravenous dose of hydrocortisone during labor and delivery ± standard deviation was 233.5 ± 129.4 mg (HD group) and 143.4 ± 38.1 mg (LD group), exhibiting a significantly larger dose in the HD group. No patients suffered an adrenal deficiency and there were no significant differences in the hemodynamics. There were three cases of puerperal endometritis, two patients with hyperglycemia, and one wound infection in the HD group, whereas one case of puerperal endometritis in the LD group. There were no significant differences in the neonatal outcomes.ConclusionPregnancy outcomes did not differ between the high and low doses of corticosteroid supplementation during labor and delivery.