CELL-PROLIFERATION AND DIFFERENTIATION IN INTRAMUCOSAL AND ADVANCED SIGNET RING CELL CARCINOMAS OF THE HUMAN STOMACH
CELL-PROLIFERATION AND DIFFERENTIATION IN INTRAMUCOSAL AND ADVANCED SIGNET RING CELL CARCINOMAS OF THE HUMAN STOMACH
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DOI：
10.1007/bf00712735
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发表时间：
1987-01-01
期刊：
影响因子：
--
通讯作者：
FUJITA, S
中科院分区：
文献类型：
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作者：
SUGIHARA, H;HATTORI, T;FUJITA, S
为了研究人胃印戒细胞癌的进展，我们比较了小的和大的粘膜内癌之间以及粘膜内癌和晚期癌之间的细胞增殖和分化。精细结构，印戒细胞分化为3种细胞类型：小窝型，腺型和肠型。粘膜中，小凹型细胞和腺型细胞分别分布于粘膜的浅部和深部。在小的粘膜癌中，上皮型细胞很少，常见到层状结构。该结构的细胞生成方式与正常胃粘膜相似，浅层的小凹型印戒细胞不增殖，中层的增殖细胞为小细胞，深层的细胞为少量腺型细胞。在大的粘膜癌和进展期癌中，上皮型细胞和增殖的小圆细胞常分布于整个粘膜的深度，并且小凹型的印戒细胞也是增殖的。这些发现表明，大部分印戒细胞癌最初形成层状结构，随着肿瘤的生长，层状结构变得模糊不清，而髓样细胞出现。然而，我们发现了几个小的晚期癌症，缺乏分层结构和卵巢型细胞。这些癌症似乎开始时没有分层结构，进展非常迅速。
In order to study the progression of signet ring cell carcinomas in the human stomach, we compared cell proliferation and differentiation between small and large intramucosal cancers, and between intramucosal and advanced cancers. Fine-structurally, signet ring cells were differentiated to 3 cell types: a foveolar, a glandular and an intestinal type. In the mucosa, the foveolar-type cells and glandular-type cells were distributed at the superficial and the deep zone, respectively. In the small mucosal cancers, intestinal-type cells were rare and a layered structure was often seen. In this structure, the mode of cell production resembled that in the normal gastric mucosa; the foveolar-type signet ring cells in the superficial layer were not proliferative and the proliferating cells were small cells in the middle layer and a few glandular-type cells in the deep layer. In the large mucosal and advanced cancers, intestinal-type cells and proliferating small round cells were often distributed throughout the depth of the mucosa, and signet ring cells of the foveolar type were also proliferative. These findings indicated that large part of the signet ring cell carcinomas initially form the layered structure and that it becomes indistinct while intestinal-type cells appear as the tumour grows. However, we found several small advanced cancers, lacking both the layered structure and the intestinal-type cells. These cancers appear to start without the layered structure and progress very rapidly.