Activation of medial temporal structures during episodic memory retrieval
Activation of medial temporal structures during episodic memory retrieval
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DOI：
10.1038/380715a0
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发表时间：
1996-04-25
期刊：
影响因子：
64.8
通讯作者：
Tulving, E
中科院分区：
文献类型：
--
作者：
Nyberg, L;McIntosh, AR;Tulving, E
内侧颞叶结构与人类情景记忆有关。患有内侧颞叶病变的患者表现出记忆缺陷(1-3)，功能性神经影像学研究表明，当对受试者样本进行数据平均时，该区域在情景编码和检索过程中被激活(4-7)。然而，这些观察结果与记忆表现的相关性仍不清楚。在这里，我们使用正电子发射断层扫描（PET）来检查大脑血液与言语情景检索的关系。我们观察到正常人类受试者的左内侧颞叶结构的检索与血流量之间存在很强的正相关性。此外，多变量分析表明，左内侧颞叶区域是区分高检索条件和低检索条件的大脑区域模式的主要组成部分。这些结果表明，内侧时间活动与检索成功相关，而不是与检索尝试相关，可能是通过反映存储模式的重新激活来实现的。
MEDIAL temporal lobe structures have been implicated in human episodic memory. Patients with medial temporal lesions show memory deficits(1-3), and functional neuroimaging studies have revealed activation in this region during episodic encoding and retrieval when data are averaged over a sample of subjects(4-7). The relevance of such observations for memory performance has remained unclear, however. Here we have used positron emission tomography (PET) to examine cerebral blood how related to verbal episodic retrieval. We observed strong positive correlations between retrieval and blood flow in left medial temporal structures in individual normal human subjects. In addition, multivariate analysis showed that regions in the left medial temporal lobe were dominant components of a pattern of brain regions that distinguished a high-retrieval condition from conditions of lower retrieval. These results suggest that medial temporal activity is related to retrieval success rather than retrieval attempt, possibly by reflecting reactivation of stored patterns.