THE HISTOPATHOLOGY OF THE PANCREAS IN TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS - A 25-YEAR REVIEW OF DEATHS IN PATIENTS UNDER 20 YEARS OF AGE IN THE UNITED-KINGDOM
THE HISTOPATHOLOGY OF THE PANCREAS IN TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS - A 25-YEAR REVIEW OF DEATHS IN PATIENTS UNDER 20 YEARS OF AGE IN THE UNITED-KINGDOM
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DOI：
10.1007/bf00452061
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发表时间：
1986-05-01
期刊：
影响因子：
8.2
通讯作者：
WEIR, RS
中科院分区：
文献类型：
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作者：
FOULIS, AK;LIDDLE, CN;WEIR, RS
对英国 19 岁及以下糖尿病患者的死亡情况进行了 25 年的计算机化调查。在 498 名已确定的患者中，有 119 名患者可以获得合适的胰腺材料。 119 名患者中，有 95 名患者的糖尿病病程已知。在 60 名患者中，这种症状的出现时间还不到 1 年。 60 名新近发病的患者中，有 47 名 (78%) 存在胰岛素炎，另外 3 名接受糖尿病治疗 1 至 6 年的患者也发现了胰岛素炎。在已发现的病例中，胰岛素炎影响了 23% 的含有胰岛素的胰岛，但仅影响了 1% 的胰岛素缺乏的胰岛，因此支持了这样的观点：胰岛素炎代表了免疫介导的胰岛素分泌 B 细胞的破坏。四名患者似乎患有与经典 1 型（胰岛素依赖型）糖尿病不同的疾病，因为没有胰岛素炎的证据，并且所有胰岛都含有胰岛素。这些患者的糖尿病发病年龄为十八个月或更小。
A 25-year computerised survey of deaths in the United Kingdom among diabetic patients of 19 years of age and under was performed. Suitable pancreatic material was available in 119 out of the 498 identified patients. The duration of diabetes was known in 95 of the 119 patients. In 60 patients it had been present for less than 1 year. Insulitis was present in 47 of the 60 patients (78%) with recent onset disease, and was also found in 3 patients who had been treated for diabetes for between 1 and 6 years. In cases in which it was identified, insulitis affected 23% of islets containing insulin, but affected only 1% of islets which were insulin deficient, thus supporting the concept that insulitis represents an immunologically mediated destruction of insulin secreting B cells. Four patients appeared to have a different disease from classical Type 1 (insulin-dependent) diabetes in that there was no evidence of insulitis and all islets contained insulin. The age of onset of diabetes was eighteen months or less in these patients.