Another approach to in vivo estimation of genetic damage in humans.
Another approach to in vivo estimation of genetic damage in humans.
复制标题
另一种体内估计人类遗传损伤的方法。
DOI：
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发表时间：
1979
影响因子：
11.1
通讯作者：
F. Mitelman
中科院分区：
文献类型：
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作者：
R. Pero;F. Mitelman
先前已通过体内染色体畸变水平升高的出现来确定对人类遗传危害的直接测量。在这里，我们报告，N-乙酰氧基-2-乙酰基-氨基芴诱导的非计划DNA合成值的个体间差异与染色体损伤的实际体内水平平行，因此，可能是人类遗传风险评估的快速有用补充。
Direct measurements of the genetic hazards to man have been determined previously by the appearance of elevated in vivo levels of chromosome aberrations. Here we report that interindividual variations in N-acetoxy-2-acetyl-aminofluorene-induced unscheduled DNA synthesis values parallel the actual in vivo levels of chromosome damage and, therefore, may be a rapid useful supplement in genetic risk assessment for humans.