Dissociable Functional Networks of the Human Dentate Nucleus
Dissociable Functional Networks of the Human Dentate Nucleus
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DOI：
10.1093/cercor/bht065
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发表时间：
2014-08-01
期刊：
影响因子：
3.7
通讯作者：
Seidler, Rachael D.
中科院分区：
文献类型：
--
作者：
Bernard, Jessica A.;Peltier, Scott J.;Seidler, Rachael D.
据报道，在非人类灵长类动物中，小脑齿状核从两个解剖上不同的区域投射到运动和前额叶皮质区域。然而，尽管大量的人类神经成像数据表明小脑与运动和认知行为有关，但缺乏可分离的运动和认知网络组成人类齿状突起的证据。为了研究人类大脑中这两个网络的存在，我们使用了静息状态功能连接磁共振成像。从背侧和腹侧齿状核的感兴趣区提取静息状态的fMRI信号。我们报告了一个涉及背齿状回、小脑前区和中央前回的“运动”网络，以及一个涉及腹侧齿状回、小腿I区和前额叶皮质的“认知”网络。这两个不同网络的存在支持了小脑参与认知任务的概念，并且超出了与运动反应成分相关的范围。
The cerebellar dentate nucleus has been reported to project to motor and prefrontal cortical regions in nonhuman primates from 2 anatomically distinct areas. However, despite a wealth of human neuroimaging data implicating the cerebellum in motor and cognitive behaviors, evidence of dissociable motor and cognitive networks comprising the human dentate is lacking. To investigate the existence of these 2 networks in the human brain, we used resting-state functional connectivity magnetic resonance imaging. The resting-state fMRI signal was extracted from regions of interest in the dorsal and ventral dentate nucleus. We report a "motor" network involving the dorsal dentate, anterior regions of the cerebellum, and the precentral gyrus, and a "cognitive" network involving the ventral dentate, Crus I, and prefrontal cortex. The existence of these 2 distinct networks supports the notion that cerebellar involvement in cognitive tasks is above and beyond that associated with motor response components.