Supramolecular Germicide Switches through Host-Guest Interactions for Decelerating Emergence of Drug-Resistant Pathogens
Supramolecular Germicide Switches through Host-Guest Interactions for Decelerating Emergence of Drug-Resistant Pathogens
复制标题
超分子杀菌剂通过主客体相互作用来减缓耐药病原体的出现
DOI：
10.1002/slct.201701546
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发表时间：
2017-09-11
期刊：
影响因子：
2.1
通讯作者：
Wang, Shu
中科院分区：
文献类型：
--
作者：
Bai, Haotian;Fu, Xuancheng;Wang, Shu
由耐药病原体引起的感染在世界各地造成了一系列公共卫生危机。为了解决这一挑战性问题，开发新的抗生素是最有效的方法之一，但不幸的是，它总是落后于抗生素耐药性的蔓延。在这项工作中，我们说明了一种创新的超分子策略，设计杀菌开关，以减缓耐药细菌的出现。杀菌剂与葫芦[7]脲（CB[7]）之间通过主客体相互作用形成杀菌开关，杀菌剂/CB[7]复合物的组装和解聚过程可逆地关闭和开启杀菌活性。结构-性能关系表明，杀菌剂活性位点与CB[7]之间的相互作用对这些杀菌开关的抗菌活性起决定性作用。通过在需要时开启抗菌活性，在不需要时关闭抗菌活性，杀菌剂开关将不会继续对细菌产生压力，从而减缓耐药细菌的出现。本工作提供了一个概念验证的方法，有效地防止耐药菌的出现，通过可控和可逆的释放和隐藏的杀菌剂活性位点的超分子策略。
Infections caused by drug-resistant pathogens have posed a series of public health crises across the world. To address this challenging issue, development of new antibiotics is one of the most effective methods, however it always lags behind the spreading of antibiotic resistance unfortunately. In this work we illustrate an innovative supramolecular strategy to design germicide switch for decelerating the emergence of drug-resistant bacteria. The germicide switches are built up between commercial germicides and cucurbit[7]uril (CB[7]) through host-guest interactions, and their bactericidal activity is switched off and on reversibly by assembly and dis-assembly processes of germicide/CB[7] complex. Structure-property relation exhibits that the interaction between active sites of germicides and CB[7] plays a decisive role in the antimicrobial activity of these germicide switches. By turning antibacterial activity on when needed and turning it off when not needed, the germicide switch will not continue to produce pressure on bacteria, thus decelerating the emergence of drug-resistant bacteria. This work offers a proof-of-concept approach to efficiently prevent the emergence of drug-resistant bacteria by controllable and reversible release and concealment of active sites of germicides by supramolecular strategy.