Fine-tuning of auditory cortex during speech production
Fine-tuning of auditory cortex during speech production
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DOI：
10.1111/j.1469-8986.2005.00272.x
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发表时间：
2005-03-01
期刊：
影响因子：
3.7
通讯作者：
Ford, JM
中科院分区：
文献类型：
--
作者：
Heinks-Maldonado, TH;Mathalon, DH;Ford, JM
当感觉信息是自我产生的运动行为（包括说话的运动行为）的结果时，皮层会抑制感觉信息。听觉皮层对自我产生语音抑制的特异性，是一种基于精确正向模型系统假设操作的预测，尚未建立。我们检查了在言语产生过程中引发的事件相关脑电位的听觉N100部分。而受试者发出一个元音。他们听到了实时反馈，包括他们不变的声音，他们的音调变化的声音，或者一个代替他们自己的声音的外星人的声音。受试者自己的未改变的声音反馈引起的N100听觉反应相对于改变的或陌生的声音反馈引起的N100听觉反应受到抑制。这与精确的前向模型的运作是一致的，该模型调节了听觉皮层对自我产生的言语的反应，并允许立即区分自我和外部产生的听觉刺激。
The cortex suppresses sensory information when it is the result of a self-produced motor act, including the motor act of speaking. The specificity of the auditory cortical suppression to self-produced speech, a prediction derived from the posited operation of a precise forward model system, has not been established. We examined the auditory N100 component of the event-related brain potential elicited during speech production. While subjects uttered a vowel. they heard real-time feedback of their unaltered voice, their pitch-shifted voice, or an alien voice substituted for their own. The subjects' own unaltered voice feedback elicited a dampened auditory N100 response relative to the N100 elicited by altered or alien auditory feedback. This is consistent with the operation of a precise forward model modulating the auditory cortical response to self-generated speech and allowing immediate distinction of self and externally generated auditory stimuli.