Oral and topical treatment of erectile dysfunction. Present and future.
Oral and topical treatment of erectile dysfunction. Present and future.
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口服和局部治疗勃起功能障碍。
DOI：
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发表时间：
1995
影响因子：
2.4
通讯作者：
M. Adams
中科院分区：
文献类型：
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作者：
A. Morales;J. Heaton;B. Johnston;M. Adams
勃起功能障碍的药物治疗取得了很大进展。然而，目前，最有效的治疗方法需要海绵体内注射，这具有许多相关的缺点。越来越多的口服和透皮制剂已被引入临床或处于其开发的不同阶段。很明显，严重的终末器官疾病可能不会导致成功的全身治疗。然而，对于勃起机制完整或轻度功能障碍的男性，非侵入性治疗可以提供一定程度的成功。目前正在进一步研究现有化合物的单独和协同活性。
A great deal of progress has been made in the pharmacological treatment of erectile dysfunction. At present, however, the most effective therapies require intracavernosal injections with a number of associated drawbacks. An increasing number of oral and transdermal agents have been introduced clinically or are at various phases in their development. It is evident that severe end-organ disease probably will not result in successful systemic therapy. Nevertheless, in men with intact or mildly dysfunctional erectile mechanisms, noninvasive treatments can offer some measure of success. Further study of individual and synergistic activity of available compounds is underway.